PMID: 9163644May 1, 1997Paper

Atopy, lung function and bronchial responsiveness in symptom-free paediatric asthma patients

The European Respiratory Journal
W GruberM S Zach

Abstract

In adolescence, some paediatric asthma patients will become symptom-free and require no further treatment. There is little information on the atopic status, lung function and bronchial responsiveness of these patients. Symptom-free asthma patients (n=118) aged 7.7-19.2 yrs, were evaluated 1 year after termination of therapy. Bronchial asthma had previously been diagnosed on the basis of recurrent wheezing episodes. Atopic status was assessed by skin-prick testing. Baseline lung function was measured by spirometry, flow-volume curve and plethysmography. Bronchial responsiveness was assessed nonpharmacologically by cold dry air challenge. Eighty one patients had at least one positive skin test result, and the remaining 37 were defined as nonatopic. In atopic subjects, the prevalence of bronchial hyperresponsiveness was significantly higher than in nonatopic patients (41 out of 81 versus 7 out of 37; p=0.001). Atopic subjects showed a significantly lower maximal expiratory flow at 25% remaining vital capacity (p<0.05) and a higher residual volume (p<0.05) than nonatopic subjects. Nonatopic subjects were significantly younger than atopic patients (p<0.01). These symptom- and medication-free paediatric and adolescent asthma patients...Continue Reading

Citations

Oct 10, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Young Yull KohChang Keun Kim
May 17, 2007·Current Opinion in Pediatrics·Caroline C Horner, Robert C Strunk
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·L M van Den ToornJ C de Jongste
Dec 12, 2001·American Journal of Respiratory and Critical Care Medicine·L M van den ToornJ B Prins
Apr 18, 2002·Allergologia et immunopathologia·F GürkanK Haspolat
Feb 1, 2008·The Journal of Allergy and Clinical Immunology·Timothy J CraigUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Oct 27, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Eduardo Vieira PonteAlvaro A Cruz
Jul 6, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Ali OzdemirOzlem Yilmaz
Jul 3, 2013·Allergy, Asthma & Immunology Research·Dong In Suh, Young Yull Koh
Jun 17, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Daniela SpallarossaGiovanni A Rossi
Apr 2, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Young Yull KohChang Keun Kim

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