Atopy patch test with house dust mite allergen--an IgE-mediated reaction?

Allergy
L HolmM Tengvall Linder

Abstract

The eczema reaction in the atopy patch test (APT) is proposed to be immunoglobulin (Ig)E mediated, but can take place also in individuals lacking allergen-specific IgE in serum. The purpose of this study was to evaluate the importance of allergen-specific serum IgE for the APT reaction. Ten patients with reproducible positive APT to extract of Dermatophagoides pteronyssinus, five patients with (group A) and five patients without (group B) detectable serum-IgE to D. pteronyssinus, were tested with extract of D. pteronyssinus on normal skin for 6, 24, 48 and 72 h. Skin biopsies were taken and analysed for cell infiltrates, eosinophils (EG2), IgE, FcepsilonRI, CD1a, CD4, CD8 and metalloproteinase 9 (MMP9). The number of IgE+, CD4+, EG2+ and MMP9+ cells increased with time in group A. FcepsilonRI+ cells and CD8+ cells increased with time in both groups. A correlation was found between the levels of D. pteronyssinus-specific serum-IgE and the score of dermal cell infiltrates at 72 h. The three patients with the highest values of allergen-specific IgE also had the highest expression of EG2+ cells and the highest APT scores. Our study strengthens the hypothesis that the IgE molecule has a key role, at least as an amplifier, in the APT...Continue Reading

References

Jan 1, 1986·Archives of Dermatological Research·C Bruynzeel-KoomenP L Bruynzeel
Jan 16, 1982·Lancet·E B MitchellT A Platts-Mills
Jan 1, 1981·Contact Dermatitis·S Fregert
Aug 1, 1993·The British Journal of Dermatology·J GrabbeB M Czarnetzki
Jul 1, 1995·The Journal of Allergy and Clinical Immunology·E G Langeveld-WildschutC A Bruijnzeel-Koomen
Mar 1, 1995·The Journal of Allergy and Clinical Immunology·U DarsowJ Ring
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology
Feb 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P L BruijnzeelC A Bruijnzeel-Koomen
May 1, 1997·International Archives of Allergy and Immunology·G Stingl, D Maurer
Nov 6, 1998·Journal of the Neurological Sciences·Y MochizukiT Takasu
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Wistokat-WülfingT Werfel
Sep 15, 1999·Allergy·M S de Bruin-WellerC A Bruijnzeel-Koomen
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Tengvall LinderC Wahlgren
May 16, 2000·The Journal of Allergy and Clinical Immunology·E G Langeveld-WildschutF C van Reijsen
Oct 14, 2000·The Journal of Allergy and Clinical Immunology·E G Langeveld-WildschutC A Bruijnzeel-Koomen
Jun 26, 2001·Journal of the American Academy of Dermatology·J RingH Behrendt
Sep 7, 2001·The Journal of Allergy and Clinical Immunology·D von BubnoffT Bieber
Sep 12, 2001·Allergy·S G JohanssonUNKNOWN EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force
Feb 28, 2002·Skin Pharmacology and Applied Skin Physiology·C Billmann-EberweinJ Krutmann
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun RatzingerNikolaus Romani
Jun 5, 2002·Current Opinion in Allergy and Clinical Immunology·Bodo Niggemann
Nov 14, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·V IngordoA Tortora
Mar 26, 2003·The British Journal of Dermatology·C JohanssonM Tengvall Linder

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Citations

Dec 29, 2007·Clinical Reviews in Allergy & Immunology·Y-S Dai
Jun 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ozlem KeskinOmer Kalayci
Sep 1, 2005·Current Opinion in Allergy and Clinical Immunology·Kristiina Turjanmaa
Jul 1, 2005·Expert Review of Clinical Immunology·S G O JohanssonHywel Williams
Jan 18, 2011·The Journal of Allergy and Clinical Immunology·Ana HenninoJean-François Nicolas
Mar 4, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Roberto RonchettiMaria Pia Villa
Jul 19, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·N GulerU Ones
Mar 6, 2007·Clinical and Experimental Dermatology·A C A DevillersA P Oranje
Apr 6, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·T GriecoF Mainiero

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