Atorvastatin added to interferon β for relapsing multiple sclerosis: a randomized controlled trial.

Journal of Neurology
Christian Philipp KammHeinrich Paul Mattle

Abstract

Statins have anti-inflammatory and immunomodulatory properties in addition to lipid-lowering effects. The present study evaluated the effect of atorvastatin added to interferon beta-1b in multiple sclerosis (MS) in a multicenter, randomized, parallel-group, rater-blinded study performed in eight Swiss hospitals. Seventy-seven patients with relapsing-remitting MS started interferon beta-1b every other day. After 3 months, they were randomized 1:1 to receive atorvastatin 40 mg/day or not in addition to interferon beta-1b until month 15. The primary endpoint was the proportion of patients with new lesions on T2-weighted images at month 15 compared to baseline at month three. At study end, the proportion of patients with new lesions on T2-weighted images was equal in both groups (odds ratio 1.14; 95 % CI 0.36-3.56; p = 0.81). All predefined secondary endpoints including number of new lesions and total lesion volume on T2-weighted images, total number of new Gd-enhancing lesions on T1-weighted images, total brain volume, volume of grey matter, volume of white matter, EDSS, MSFC, relapse rate, time to first relapse, number of relapse-free patients and neutralizing antibodies did not show any significant differences (all p values >0.1...Continue Reading

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Citations

Mar 25, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rosella CiurleoSilvia Marino
Nov 13, 2015·Inflammopharmacology·Daniel May de OliveiraJean Pierre Schatzmann Peron
Mar 22, 2015·CNS Drugs·Gorm Pihl-JensenJette Lautrup Frederiksen
Mar 25, 2014·Journal of the Neurological Sciences·Prudence TetteyIngrid van der Mei
Dec 3, 2014·Journal of the Neurological Sciences·Prudence TetteyIngrid A F van der Mei
Aug 21, 2013·Multiple Sclerosis : Clinical and Laboratory Research·C van de KraatsC E Teunissen
Dec 6, 2014·Hospital Pharmacy·Joyce A Generali, Dennis J Cada
Jul 11, 2019·CNS Drugs·Moritz FörsterDavid Kremer
Jul 22, 2018·Neurology. Neuroimmunology and Neuroinflammation·Xavier MontalbanFernando Dangond
Mar 7, 2020·Gut·Jaime BoschJuan G Abraldes
May 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Rhonda R VoskuhlYuichiro Itoh
Nov 22, 2016·Lipid Insights·Jonathan T DaviesHollie I Swanson
Aug 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Akshaya RameshMichael R Wilson
Mar 4, 2021·Current Opinion in Gastroenterology·Mohamad Kareem Marrache, Don C Rockey

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