Atorvastatin and cardiac hypertrophy and function in hypertrophic cardiomyopathy: a pilot study

European Journal of Clinical Investigation
Sherif F NaguehAli J Marian

Abstract

Hypertrophic cardiomyopathy (HCM) is a genetic paradigm of cardiac hypertrophy. Cardiac hypertrophy is a major determinant of risk of sudden death and morbidity in HCM. Treatment with statins reverses hypertrophy in animal models of HCM. Thus, statins may afford therapeutic benefits in HCM. We performed a feasibility study with atorvastatin to gather the pre-requisite data for designing randomized efficacy studies. We screened 32 patients with HCM in 18months. Twenty-one patients met the study criteria and consented to participate. The demographics and echocardiographic phenotype of those who did and those who did not participate were not significantly different. We treated the participants with escalating doses of atorvastatin (20, 40 and 80mgday(-1) ) for 2years. We performed ECG and echocardiography and measured plasma lipids, liver enzymes, creatine kinase and B-type natriuretic peptide levels before and after 3, 6, 12 and 24months of therapy. Fifteen, 12 and 11 patients completed 6, 12 and 24months of therapy respectively. Six patients discontinued atorvastatin because of perceived lack of benefit. We stopped atorvastatin in 4 patients because of modest elevations in liver enzymes, creatine kinase or back pain. The charact...Continue Reading

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Citations

Jun 22, 2012·European Heart Journal·Roberto SpoladoreIacopo Olivotto
Sep 12, 2013·Pharmacology & Therapeutics·Dimitris TousoulisChristodoulos Stefanadis
Nov 1, 2015·The Canadian Journal of Cardiology·Fady Hannah-ShmouniDaniel Jacoby
Sep 18, 2010·European Journal of Clinical Investigation·Karam M Kostner
Apr 26, 2016·European Journal of Heart Failure·Enrico AmmiratiIacopo Olivotto
Sep 6, 2014·Frontiers in Physiology·Styliani Vakrou, M Roselle Abraham
Apr 2, 2014·Angiology·Panagiotis AnagnostisAsterios Karagiannis
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Sep 2, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lorenzo SantiniRaffaele Coppini
May 14, 2021·Circulation Research·A J Marian

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