Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis

Journal of Inflammation
K L C da SilvaMario José Abdalla Saad

Abstract

Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Statins and diacerein have pleiotropic effects, such as the blockage of inflammatory signaling pathways, suggesting that these drugs may be an attractive therapeutic or prophylactic strategy against sepsis. The aim of the present study was to investigate whether a statin or diacerein can improve insulin signaling, disease tolerance and survival in sepsis by inhibiting inflammatory pathways. We investigated the effect of these drugs on survival, tissue insulin signaling and inflammatory pathways in the liver and muscle of rats with sepsis induced by cecal ligation and puncture (CLP). The results showed that administration of medications, with anti-inflammatory ability, to septic animals increased survival and improved disease tolerance and insulin resistance in the liver and muscle. The treatment also attenuated ER stress, NF-κB, JNK activ...Continue Reading

References

Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Aug 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L A DostalJ A Anderson
Sep 1, 1997·The Journal of Clinical Investigation·H BöhrerP P Nawroth
Jun 9, 1998·Osteoarthritis and Cartilage·A R MooreD A Willoughby
Dec 5, 1998·Clinical Pharmacokinetics·P NicolasO Petitjean
Jan 23, 1999·The New England Journal of Medicine·A P Wheeler, G R Bernard
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A P LiappisG L Simon
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon
Jul 20, 2002·European Journal of Pharmacology·Tadafumi TamuraNagatomo Takafumi
Nov 26, 2002·Nature·Jiro HirosumiGökhan S Hotamisligil
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Kuang-Yao YangEdward Abraham
Aug 9, 2003·Chest·Yaniv Almog
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Mar 3, 2004·Intensive Care Medicine·Paul E Marik, Murugan Raghavan
Jul 20, 2004·Current Opinion in Critical Care·John C Marshall
Feb 3, 2005·Nature Medicine·Melek C ArkanMichael Karin
Nov 12, 2005·Intensive Care Medicine·Peter KrugerGraeme Nimmo
Feb 18, 2006·Critical Care Medicine·Reimar W ThomsenHans-Henrik Lervang
Mar 11, 2006·American Journal of Respiratory and Critical Care Medicine·John ArcaroliEdward Abraham
Mar 21, 2006·Surgery·Austin L Spitzer, Hobart W Harris
Mar 24, 2006·The Lancet Infectious Diseases·Marius TerblancheDaniel G Hackam
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jan 10, 2009·Nature Protocols·Daniel RittirschPeter A Ward
Oct 14, 2009·Archives of Internal Medicine·Imad M TleyjehTalal Ibrahim
Mar 21, 2013·JAMA : the Journal of the American Medical Association·Steven M OpalUNKNOWN ACCESS Study Group
Jan 5, 2014·Cold Spring Harbor Perspectives in Biology·Jérémie BoucherC Ronald Kahn
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Sep 14, 2016·Clinical Diabetes : a Publication of the American Diabetes Association·Vidhya D S IlluriGrazia Aleppo

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

QuantStudio
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.