Atorvastatin causes regression of endometriotic implants in a rat model

Reproductive Biomedicine Online
Bulent YilmazOrhan Aksakal

Abstract

Endometriotic implants were induced surgically in female Wistar albino rats, which were randomly divided into three groups. The rats in group I (n=10) and group II (n=9) were given 2.5 mg/kg/day intraperitoneal and oral atorvastatin, respectively, for 28 days. Group III (n=9) was given no medication (control). The mean volume and weight of explants in group I were significantly lower (both P < 0.05) compared with group III. Histopathological score of the implants was significantly lower in groups I and II, when compared with group III (P < 0.01 and P < 0.05, respectively). There were significant reductions in explant concentrations of vascular endothelial growth factor and matrix metalloproteinase 9 in group I (P < 0.01 and P < 0.001, respectively) and group II (both P < 0.01) compared with group III while staining due to tissue inhibitor of metalloproteinase 2 was significantly higher in group I (P < 0.01) and group II (P < 0.01) compared with group III. Moreover, explant concentration of superoxide dismutase was significantly increased in groups I and II compared with group III (both P < 0.05). In conclusion, atorvastatin causes significant regression of endometriotic implants in rats. Moreover, intraperitoneal atorvastatin s...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Oct 1, 1996·Human Reproduction·S K Smith
Nov 5, 1997·Annals of the New York Academy of Sciences·R N TaylorJ F Tseng
Jun 17, 1998·Fertility and Sterility·A A MurphyS Parthasarathy
Feb 23, 1999·Human Reproduction Update·D L HealyM Wingfield
Jan 15, 2000·Journal of the American College of Cardiology·C J VaughanC T Basson
Mar 10, 2000·Biochimica Et Biophysica Acta·K BrewH Nagase
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Sven WassmannGeorg Nickenig
May 16, 2002·Fertility and Sterility·Anne Van LangendoncktJacques Donnez
Jun 27, 2002·Journal of the American College of Cardiology·Hannes Franz AlberFranz Weidinger
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Kevin G OsteenKaylon L Bruner-Tran
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·M Louise HullStephen K Smith
Dec 3, 2003·Annals of the New York Academy of Sciences·Rafael F Valle, John J Sciarra
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Annemiek W NapPatrick G Groothuis
Aug 2, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Daniele Del RioNicoletta Pellegrini
Mar 31, 2006·Biology of Reproduction·Piotr C PiotrowskiAntoni J Duleba
May 23, 2006·Journal of the Society for Gynecologic Investigation·Dilek UygurSertaç Batioglu
Aug 31, 2006·Expert Opinion on Emerging Drugs·Attila MihalyiThomas M D'Hooghe
Jan 20, 2007·Human Reproduction·Mesut OktemHulusi B Zeyneloglu
Mar 23, 2007·Acta Pharmacologica Sinica·Gang ChengXiao-feng Bao
Jun 22, 2007·Fertility and Sterility·Mehmet GüneyTamer Mungan
Jul 25, 2007·Current Opinion in Plant Biology·Edward E Farmer, Céline Davoine
Jan 25, 2008·Clinical and Experimental Hypertension : CHE·Takuya KishiKenji Sunagawa
Mar 21, 2009·Reproductive Biomedicine Online·Bulent YilmazLeyla Mollamahmutoglu
Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Kaylon L Bruner-TranAntoni J Duleba

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Citations

Jan 23, 2013·The Journal of Clinical Endocrinology and Metabolism·Anna SokalskaAntoni J Duleba
Dec 2, 2015·Expert Opinion on Investigational Drugs·Umberto Leone Roberti Maggiore, Simone Ferrero
Mar 24, 2012·Expert Opinion on Emerging Drugs·Isabelle StreuliCharles Chapron
Sep 1, 2015·Women's Health·Rukset Attar, Erkut Attar
Jun 27, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luciano GibranSergio Podgaec
Sep 4, 2012·Fertility and Sterility·Sérgio Reis SoaresAntonio Pellicer
Apr 12, 2012·Biology of Reproduction·Anna SokalskaAntoni J Duleba
Jun 24, 2017·Biology of Reproduction·Hugh S TaylorAntoni J Duleba
Jun 8, 2017·Clinical Obstetrics and Gynecology·Saima Rafique, Alan H Decherney
Mar 29, 2018·Reproductive Sciences·Emine CosarHugh S Taylor
Jan 13, 2018·Reproductive Sciences·Burak ZeybekMostafa A Borahay
May 1, 2018·Expert Opinion on Investigational Drugs·Fabio BarraSimone Ferrero
Jul 6, 2018·Expert Opinion on Pharmacotherapy·Simone FerreroFabio Barra
May 20, 2015·Molecular Reproduction and Development·Xiao-Hang CheHong Zhu
Jul 1, 2014·Current Opinion in Obstetrics & Gynecology·Lieven Platteeuw, Thomas D'Hooghe
Jun 14, 2013·Current Opinion in Obstetrics & Gynecology·Richard O Burney
Dec 17, 2018·Journal of Assisted Reproduction and Genetics·Anna SokalskaAntoni J Duleba
Nov 8, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Weilin ZhengXuefang Liang
Apr 11, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Guanghui ZhuYing Cao
May 8, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Masoumeh GhafarzadehZahra Marzban Rad
May 20, 2021·Minerva Obstetrics and Gynecology·Simona MartoneStefano Luisi
May 26, 2021·Obstetrical & Gynecological Survey·Nikolaos ThanatsisApostolos Kaponis

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