Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH.

Journal of Gastroenterology
Yuki KimuraKazuaki Chayama

Abstract

Advanced glycation endproducts (AGEs), final reaction products of protein with sugars, are known to contribute to various disorders, including diabetes, aspects of aging, and neurodegenerative diseases. Recently, we reported elevated levels of serum AGEs in patients with nonalcoholic steatohepatitis (NASH); further, we found that AGEs induced the generation of reactive oxygen species followed by the proliferation and activation of hepatic stellate cells, a major contributor to liver fibrosis. In this study, to explore the clinical usefulness of AGEs as a biomarker for the attenuation of NASH, we investigated whether the treatment of NASH with dyslipidemia could decrease serum levels of AGEs. This study included 43 patients with biopsy-proven NASH with dyslipidemia. Serum glyceraldehyde-derived AGE measurements and clinical laboratory tests were performed periodically during an open-label study of atorvastatin (10 mg daily) for 12 months. Standard weight-loss counseling was continued during the treatment period. Oral glucose tolerance tests and liver density assessment by computerized tomography were performed before and after treatment. Follow-up liver biopsy was performed in 22 patients. All 43 patients had dyslipidemia. The b...Continue Reading

References

Aug 1, 1995·Journal of Medical Ethics·J Harris
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M R TeliC P Day
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Jun 24, 2000·Annals of the New York Academy of Sciences·Y YamamotoH Yamamoto
Jul 18, 2001·The Journal of Clinical Investigation·Y YamamotoH Yamamoto
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Jan 19, 2002·Biochemical and Biophysical Research Communications·Sho-ichi YamagishiZenji Makita
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
Sep 17, 2003·Journal of Gastroenterology and Hepatology·Jason M Hui, Geoffrey C Farrell
Dec 18, 2003·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Murat KiyiciFaruk Memik
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jul 19, 2005·Current Pharmaceutical Design·Sho-ichi Yamagishi, Tsutomu Imaizumi
Oct 18, 2005·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nobuo Yoshiike, Htay Lwin
May 16, 2006·Alimentary Pharmacology & Therapeutics·E Gómez-DomínguezR Moreno-Otero
May 20, 2006·Current Medical Research and Opinion·Vasilios G AthyrosMoses S Elisaf
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Hideyuki HyogoSusumu Tazuma
May 7, 2008·Journal of Gastroenterology·Keiko IwamotoKazuaki Chayama
May 14, 2008·Current Pharmaceutical Design·Hideyuki Hyogo, Sho-ichi Yamagishi
Nov 18, 2008·Metabolism: Clinical and Experimental·Hideyuki HyogoKazuaki Chayama
Jul 29, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sho-Ichi YamagishiMasayoshi Takeuchi

❮ Previous
Next ❯

Citations

Oct 20, 2010·Amino Acids·Ravichandran RamasamyAnn Marie Schmidt
Jan 19, 2013·Current Atherosclerosis Reports·William Nseir, Mahmud Mahamid
Jan 11, 2013·International Journal of Hepatology·Kei Nakajima
Nov 14, 2012·Therapeutic Advances in Endocrinology and Metabolism·Alexandra Bargiota, Evanthia Diamanti-Kandarakis
Aug 8, 2013·PloS One·Nobuhiko HayashiMikihiro Tsutsumi
Oct 3, 2013·International Journal of Molecular Sciences·Juliana Célia de F SantosMarília O F Goulart
May 4, 2012·World Journal of Gastroenterology : WJG·Junichi TakinoMasayoshi Takeuchi
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Emmanuel A Tsochatzis, George V Papatheodoridis
Aug 9, 2013·Antioxidants & Redox Signaling·Soo LimKwang Kon Koh
May 21, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Cynthia HerrickAnne Carol Goldberg
Aug 19, 2014·Journal of Atherosclerosis and Thrombosis·Soo Lim, Philip Barter
Mar 20, 2010·Journal of Gastroenterology·Ilker Tasci
Apr 14, 2010·Journal of Gastroenterology·Yusuf Yilmaz
Mar 16, 2012·Digestive Diseases and Sciences·William NseirMurad Ghali
Feb 20, 2016·Endocrinology and Metabolism Clinics of North America·Cynthia HerrickEdward A Gill
Jul 20, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hideyuki HyogoKazuaki Chayama
Jan 24, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hideyuki HyogoKazuaki Chayama
Nov 24, 2011·Journal of Clinical Lipidology·Maria Tzefos, Jacqueline L Olin
Feb 23, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mariko Hojo, Sumio Watanabe
Sep 29, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideyuki HyogoSusumu Tazuma
Apr 4, 2012·Alimentary Pharmacology & Therapeutics·Y Yilmaz
May 16, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takashi NakaharaKazuaki Chayama
Oct 26, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masafumi Ono
Jan 3, 2013·Diabetes, Obesity & Metabolism·L EngelenC G Schalkwijk
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomokazu IshitobiKazuaki Chayama
Oct 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Shira Zelber-SagiOren Shibolet
Aug 4, 2015·Metabolism: Clinical and Experimental·Konstantinos TziomalosAsterios Karagiannis
May 10, 2015·Medical Hypotheses·Ivanildo Coutinho de Medeiros, Josivan Gomes de Lima
Apr 19, 2015·European Journal of Medical Research·Sho-ichi Yamagishi, Takanori Matsui
May 6, 2015·Cardiology Clinics·Cynthia HerrickEdward A Gill
May 31, 2016·Metabolism: Clinical and Experimental·Niki KatsikiChristos S Mantzoros

❮ Previous
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