Atorvastatin may delay cardiac aging by upregulating peroxisome proliferator-activated receptors in rats

Pharmacology
Lei HanPing Ye

Abstract

To investigate the effect of atorvastatin on cardiac aging in rats. Ninety 20-month-old Wistar rats were administered oral atorvastatin (AVT; 10 or 1 mg·kg(-1)·day(-1)) or saline for 4 months. At the end of the experiment, age-related changes in hearts were measured. Compared with young rats, obvious increases were found in the aging rats in left ventricle thickness, diameter of cardiocytes, collagen deposition, the ratio of type I/type III collagen, β-galactosidase and malondialdehyde (MDA), and obvious decreases were found in superoxide dismutase (SOD), catalase (CAT) and nitric oxide synthase (NOS). The treatment with AVT led to significant decreases in the thickness of the left ventricle, diameter of cardiocytes, collagen deposition, I/III collagen ratio, MDA, β-galactosidase and increases in the activity of SOD, CAT and NOS. Some aging-related inflammatory cytokines like interleukin (IL)-1β, tumour necrosis factor (TNF)-α and matrix metalloproteinase (MMP)-9 were found to be overexpressed in the aging rats. AVT treatment could inhibit the expression of IL-1β, TNF-α and MMP-9 on both the mRNA and protein levels, and increase the expression of peroxisome proliferator-activated receptors (PPAR-α/β/δ/γ). Pretreatment with PPAR...Continue Reading

References

Jul 1, 1994·The American Journal of Physiology·R N MichelO H Lowry
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y M LiH Vlassara
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·B CormanB I Levy
Oct 22, 1998·La Revue du praticien·P Giral
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·C Janeway, R Medzhitov
Sep 29, 2000·Biochemical Pharmacology·B P NeveB Staels
Jun 9, 2001·Ultrasound in Medicine & Biology·C T NguyenS A Wickline
Oct 3, 2002·Nature Reviews. Immunology·Raymond A Daynes, Dallas C Jones
Aug 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaomin ZhangJeanne Y Wei
Aug 5, 2004·Journal of Biomedicine & Biotechnology·Jihan Youssef, Mostafa Badr
Jan 12, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sharon JudgeChristiaan Leeuwenburgh
Feb 1, 2005·Annals of the New York Academy of Sciences·Patrick L McGeer, Edith G McGeer
May 21, 2005·Immunity & Ageing : I & a·Federico LicastroCalogero Caruso
Sep 14, 2006·Fundamental & Clinical Pharmacology·Julien BeckerFrançoise Pons
Feb 21, 2007·Hypertension·Pasquale StrazzulloFrancesco P Cappuccio
May 15, 2008·American Journal of Physiology. Endocrinology and Metabolism·Christos TikellisJosephine M Forbes
Jul 5, 2008·Journal of Applied Physiology·Anna CsiszarZoltan Ungvari
Oct 14, 2009·Circulation·Anthony J Muslin
Oct 14, 2009·Circulation·Yasutaka InuzukaTetsuo Shioi
Nov 13, 2010·Biochimica Et Biophysica Acta·David Alvarez-GuardiaManuel Vázquez-Carrera
Feb 10, 2011·Endocrinology·James P SticeAnne A Knowlton

❮ Previous
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Citations

Sep 5, 2013·International Journal of Molecular Sciences·Krishnan VenkataramanT C Tai
Dec 3, 2014·Experimental Gerontology·Miriam GranadoÁngel Luis García-Villalón
Dec 30, 2015·PPAR Research·Christine J PolKonstantinos Drosatos
Oct 10, 2014·British Journal of Pharmacology·O PechánováP Ferdinandy
Aug 26, 2016·Pathobiology of Aging & Age Related Diseases·Konstantinos Drosatos
Aug 18, 2017·Antioxidants & Redox Signaling·Francesco VioliDaniele Pastori
May 14, 2016·Circulation Research·Irene AlfarasRafael de Cabo
Nov 29, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Cesar A MeschiariJose E Tanus-Santos
Apr 22, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Toru MiyoshiHiroshi Ito
May 4, 2017·Lipids in Health and Disease·Meng-Jie ZhaoHong Xiao
Aug 15, 2017·Journal of Atherosclerosis and Thrombosis·Tsuyoshi Nozue
Nov 28, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tomasz A BondaKarol A Kamiński
Oct 19, 2013·Experimental and Therapeutic Medicine·Lei HanXin Liu
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali Mohammad Pourbagher-ShahriJurga Bernatoniene

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