Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells.

Atherosclerosis
Agnieszka LobodaJozef Dulak

Abstract

Beneficial cardiovascular effects of statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are particularly assigned to the modulation of inflammation. Endothelial nitric oxide synthase (eNOS) and heme oxygenase-1 (HO-1) are listed among the crucial protective, anti-inflammatory genes in the vasculature. Here we show that atorvastatin at pharmacologically relevant concentration (0.1 microM) enhanced the expression of eNOS in human microvascular endothelial cells (HMEC-1). Moreover, atorvastatin prevented hypoxia-induced decrease in eNOS expression. However, in the same cells atorvastatin was ineffective in modulation of HO-1 protein level. Therefore, we suggest that the protective effect of statins at their pharmacological concentrations is not mediated by enhancement of HO-1 activity, but may involve eNOS.

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Citations

Sep 8, 2007·Antioxidants & Redox Signaling·Cheng LiRoland Stocker
Sep 25, 2007·Antioxidants & Redox Signaling·Shigeki ShibaharaKazuhisa Takeda
Sep 12, 2007·Antioxidants & Redox Signaling·Jozef Dulak
Jun 26, 2008·Antioxidants & Redox Signaling·Agnieszka LobodaJozef Dulak
Mar 4, 2009·Antioxidants & Redox Signaling·Agnieszka LobodaJozef Dulak
Jul 14, 2010·Antioxidants & Redox Signaling·Young-Myeong KimHun-Taeg Chung
Dec 13, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ching-Hua HsiehShun-Sheng Chen
Sep 5, 2008·Current Opinion in Lipidology·Jozef DulakAlicja Jozkowicz
Nov 5, 2013·Antioxidants & Redox Signaling·Louise L DunnRoland Stocker
Sep 29, 2007·Canadian Journal of Physiology and Pharmacology·Lucie MuchovaDavid K Stevenson
Feb 20, 2009·British Journal of Pharmacology·G HeebaT Malinski
Nov 22, 2011·Microvascular Research·J LuoP Grammas
Aug 10, 2012·Circulation. Cardiovascular Interventions·Martin K C NgWilliam F Fearon
Nov 12, 2014·Postgraduate Medicine·Giulia RoveriPaolo Ventura
Oct 24, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·Mojca LunderMišo Šabovič
Feb 17, 2019·Cellular and Molecular Life Sciences : CMLS·Paulina PodkalickaAgnieszka Loboda
May 11, 2018·Oxidative Medicine and Cellular Longevity·Aleksandra Piechota-PolanczykAlicja Jozkowicz
Nov 2, 2020·International Journal of Biological Macromolecules·Annapoorna Mohandas, Jayakumar Rangasamy

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