Atorvastatin protects BV‑2 mouse microglia and hippocampal neurons against oxygen‑glucose deprivation‑induced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NF‑κB pathway

Molecular Medicine Reports
Jian HanFu-Qiang Guo

Abstract

Atorvastatin is a member of the statin class of drugs, which competitively inhibit the activity of 5‑hydroxy‑3‑methylglutaryl‑coenzyme A reductase. The aim of the present study was to assess whether atorvastatin may protect BV‑2 microglia and hippocampal neurons against oxygen‑glucose deprivation (OGD)‑induced neuronal inflammatory injury and to determine the underlying mechanisms by which its effects are produced. Cell viability and apoptotic ability were assessed using an MTT assay and annexin V‑fluorescein isothiocyanate/propidium iodide double staining followed by flow cytometry, respectively. The expression of inflammation and apoptosis‑associated mRNAs and proteins were assessed using reverse transcription‑quantitative polymerase chain reaction and western blotting, and the expression of inflammatory factors was determined using ELISA. The results of the current study revealed that atorvastatin treatment suppressed the viability of OGD BV‑2 microglia and hippocampal neurons. Furthermore, atorvastatin treatment reduced the expression of proinflammatory factors in OGD BV‑2 microglia. Additionally, it was demonstrated to downregulate the toll‑like receptor 4 (TLR4)/tumor necrosis factor receptor‑associated factor 6 (TRAF6)/n...Continue Reading

References

Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·J YrjänheikkiJ Koistinaho
Jun 13, 2000·Alzheimer Disease and Associated Disorders·P EikelenboomW A van Gool
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 3, 2004·Journal of Neuroinflammation·Wolfgang J StreitW Sue T Griffin
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew Cordle, Gary Landreth
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·James K Liao, Ulrich Laufs
Nov 12, 2005·Stroke; a Journal of Cerebral Circulation·Benjamin D HoehnGary K Steinberg
May 6, 2006·The Journal of Allergy and Clinical Immunology·Tsuneyasu Kaisho, Shizuo Akira
Sep 29, 2006·Journal of Alzheimer's Disease : JAD·José Manuel Martínez Lage
Nov 1, 2006·Biochemical Society Transactions·S L Stevens, M P Stenzel-Poore
May 1, 2007·Trends in Immunology·Kelly L BrownRobert E W Hancock
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Silke WalterKlaus Fassbender
May 31, 2008·Journal of Neuroinflammation·Jing-Ji JinKen-Ichiro Fukuchi
Nov 22, 2008·Stroke; a Journal of Cerebral Circulation·Alessandra ValerioEnzo Nisoli
Dec 18, 2008·The FEBS Journal·Diana AmanteaMaria T Corasaniti
Aug 6, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carol A Colton
Mar 18, 2010·Nature Reviews. Neurology·V Hugh PerryClive Holmes
Jun 17, 2010·Journal of Neural Transmission·C Y Daniel Lee, Gary E Landreth
Aug 3, 2010·Current Cardiology Reviews·David J KaczorowskiTimothy R Billiar
Aug 10, 2010·Biological Psychiatry·Walter SwardfagerNathan Herrmann
Aug 12, 2010·Current Pharmaceutical Design·Paula AgostinhoCatarina Oliveira
Nov 16, 2010·Journal of Neuroscience Methods·Richard GordonArthi Kanthasamy
Mar 19, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer's Association
Apr 3, 2012·The Journal of Clinical Investigation·Eva Czirr, Tony Wyss-Coray
Jan 12, 2013·Science·Adriano AguzziMariko L Bennett
Nov 7, 2013·Folia medica·Maria T Georgieva-Kotetarova, Ivanka I Kostadinova
Apr 9, 2014·Journal of Neuropathology and Experimental Neurology·Raffaella GesueteMary P Stenzel-Poore

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