Atorvastatin reduces cardiac and adipose tissue inflammation in rats with metabolic syndrome

International Journal of Cardiology
Yuichiro YamadaKohzo Nagata

Abstract

Statins are strong inhibitors of cholesterol biosynthesis and help to prevent cardiovascular disease. They also exert additional pleiotropic effects that include an anti-inflammatory action and are independent of cholesterol, but the molecular mechanisms underlying these additional effects have remained unclear. We have now examined the effects of atorvastatin on cardiac and adipose tissue inflammation in DahlS.Z-Leprfa/Leprfa (DS/obese) rats, which we previously established as a model of metabolic syndrome (MetS). DS/obese rats were treated with atorvastatin (6 or 20mgkg-1day-1) from 9 to 13weeks of age. Atorvastatin ameliorated cardiac fibrosis, diastolic dysfunction, oxidative stress, and inflammation as well as adipose tissue inflammation in these animals at both doses. The high dose of atorvastatin reduced adipocyte hypertrophy to a greater extent than did the low dose. Atorvastatin inhibited the up-regulation of peroxisome proliferator-activated receptor γ gene expression in adipose tissue as well as decreased the serum adiponectin concentration in DS/obese rats. It also activated AMP-activated protein kinase (AMPK) as well as inactivated nuclear factor-κB (NF-κB) in the heart of these animals. The down-regulation of AMPK...Continue Reading

Citations

Jun 14, 2019·Journal of the American Heart Association·Paolo RaggiArthur E Stillman
Jul 6, 2019·Journal of Cardiovascular Pharmacology·Undurti N Das
Nov 19, 2019·Minerva endocrinologica·Michael DoulberisJannis Kountouras
Jun 28, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Silke RyanJean-Louis Pépin
Nov 22, 2019·Frontiers in Physiology·Domenico D'AmarioFilippo Crea
Nov 21, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Yuki KomatsuKohzo Nagata
Feb 13, 2021·Frontiers in Cardiovascular Medicine·Weili ShiKeji Chen
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nahla E El-AshmawyAsmaa A Kamel
Mar 5, 2018·European Journal of Pharmacology·Massa OiEugene F du Toit
Jun 24, 2021·Arquivos brasileiros de cardiologia·Karine Ferreira da Silva CarvalhoRafael Menezes da Costa

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