Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats

Clinical and Experimental Hypertension : CHE
Takuya KishiKenji Sunagawa

Abstract

Previously, we demonstrated that atorvastatin has sympatho-inhibitory effects with the upregulation of nitric oxide synthase in the brain in stroke-prone spontaneously hypertensive rats (SHRSP), and that reactive oxygen species in the rostral ventrolateral medulla (RVLM), where the vasomotor center is located, mediate the sympatho-excitatory effect. The aim of the present study was to determine if atorvastatin reduces oxidative stress in the RVLM of SHRSP along with the sympatho-inhibitory effect. SHRSP and Wistar-Kyoto (WKY) rats received standard feed with atorvastatin (50mg/kg per day) or standard feed for 30 days. Systolic blood pressure and heart rate were evaluated using the tail-cuff method. Urinary norepinephrine excretion was measured for 24 hours. After 30 days in SHRSP, blood pressure and urinary norepinephrine excretion were significantly lower in the atorvastatin group than in the control group. Thiobarbituric acid-reactive substance (TBARS) levels in the RVLM tissue obtained using the micropunch technique were used as measures of oxidative stress. Prior to the treatment, TBARS levels in the RVLM of SHRSP were significantly higher than those of WKY. After 30 days, TBARS levels in the RVLM of SHRSP were significantl...Continue Reading

References

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Citations

Sep 19, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shuichiro ArakiKenji Sunagawa
May 11, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takuya KishiKenji Sunagawa
Aug 25, 2012·Cardiology Research and Practice·Takuya Kishi, Yoshitaka Hirooka
Feb 20, 2013·Antioxidants & Redox Signaling·Samuel H H Chan, Julie Y H Chan
Jan 13, 2009·Cardiovascular Research·Ariane SchmechelThomas Eschenhagen
Dec 17, 2009·Clinical and Experimental Hypertension : CHE·Takuya KishiKenji Sunagawa
May 15, 2012·Clinical and Experimental Hypertension : CHE·Takuya KishiKenji Sunagawa
Feb 2, 2010·Reproductive Biomedicine Online·Bulent YilmazOrhan Aksakal
Jul 25, 2008·Autonomic Neuroscience : Basic & Clinical·Yoshitaka Hirooka
Jul 31, 2013·British Journal of Pharmacology·Wen-Han ChengChing-Jiunn Tseng
Dec 23, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki KogaKenji Sunagawa
Nov 28, 2013·Clinical Science·Philip J Millar, John S Floras
Oct 12, 2010·Journal of Molecular and Cellular Cardiology·Neil HerringDavid J Paterson
Feb 4, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshitaka HirookaKenji Sunagawa
Apr 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka HirookaKenji Sunagawa
Nov 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Takuya Kishi, Yoshitaka Hirooka

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