Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits

Clinica Chimica Acta; International Journal of Clinical Chemistry
Jie-Qi LiPing Li

Abstract

Plasminogen activator inhibitor-1 (PAI-1) expression are increased in adipose tissues/adipocytes of obese mice, which is associated with a hypofibrinolytic state that contributes to thrombosis. We recently demonstrated that PAI-1 expression increases in adipose tissues/adipocytes of cholesterol-fed rabbits. In this study, we evaluated the ability of atorvastatin to modulate PAI-1 expression in cholesterol-fed rabbits and the regulatory mechanism. Male rabbits were randomly fed with normal diet and high-cholesterol diet for 8 weeks, following 4 weeks, those fed high-cholesterol diet were randomly assigned to 2.5 mg/kg/day atorvastatin or starch. At the end of 12 weeks, subcutaneous adipose was collected, and culture adipocyte. PAI-1 mRNA was detected by RT-PCR. PAI-1 concentrations were determined with ELISA. The effect of atorvastatin and mevalonate (MVA) on PAI-1 production in adipocytes in vitro was observed. Atorvastatin significantly reduced serum TC and LDL-C concentrations (p<0.05), and decreased plasma PAI-1 concentration and PAI-1 expression in adipose tissues/adipocytes from cholesterol-fed rabbits. In vitro, atorvastatin dose-dependently suppressed PAI-1 expression and protein secretion in adipocytes. MVA reversed the...Continue Reading

References

Sep 12, 2000·Current Cardiology Reports·R S Rosenson
Jun 28, 2002·Experimental Gerontology·Patrick L McGeerKoji Yasojima
Aug 26, 2003·Journal of Cellular Biochemistry·Ronald A MarkleAndrew C Nicholson
Oct 8, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shui-Ping ZhaoHuijun Ye

❮ Previous
Next ❯

Citations

Apr 9, 2009·International Journal of Hematology·Koji YamamotoJunki Takamatsu
Apr 16, 2009·Cardiology in Review·Maulik D MajmudarJoseph E Marine
Oct 3, 2013·American Journal of Respiratory and Critical Care Medicine·Jaimin M PatelElizabeth Sapey
Jul 30, 2014·European Journal of Clinical Investigation·Valentina PecoraroSilvio Garattini
Jul 20, 2021·Biomedical Reports·Michal NohawicaMarzena Wyganowska-Swiatkowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.