Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke

The International Journal of Neuroscience
Jingmiao ZhangYonglu Huang

Abstract

Statins have a positive impact on ischemic stroke outcome. It has been reported that statin have neuroprotective function after ischemic stroke in addition to lipid-lowering effect in animal model. However, the neuroprotective function of statin after stroke has not been confirmed in clinical studies. The aim of this study was to evaluate in a clinical model if statins induce neuroprotection after stroke. We, therefore, assessed serum brain-derived neurotrophic factor (BDNF) levels and functional recovery in atherothrombotic stroke patients and investigated their relationship with atorvastatin treatment. Seventy-eight patients with atherothrombotic stroke were enrolled and randomly assigned to atorvastatin treatment group or placebo control group. Neurological function after stroke was assessed with the National Institutes of Health Stroke Scale, modified Rankin Scale (mRS) and Barthel Index (BI). The serum BDNF levels were both measured at 1 day and 6 weeks after stroke. Linear regression was used to assess the association between BDNF levels and neurological function scores. The mRS and BI were markedly improved in the atorvastatin group when compared to placebo at 6 weeks after stroke. The serum BDNF levels in atorvastatin g...Continue Reading

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Citations

Sep 16, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Susumu YamaguchiTakayuki Matsuo
Sep 7, 2019·Journal of Neurosurgical Anesthesiology·James E Cottrell, John Hartung
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Jun 14, 2020·European Journal of Pharmacology·Arash AbdolmalekiAbolfazl Bayrami
Dec 22, 2020·Mediators of Inflammation·Dariusz KotlegaMalgorzata Szczuko
Apr 4, 2021·Medicina·Eleni KarantaliIoannis Mavroudis
Jul 29, 2017·Behavioural Brain Research·Elham KavianiIman Fatemi
Aug 24, 2021·Journal of Molecular Neuroscience : MN·Pragya GirotraSimona Bungau

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