Atorvastatin Upregulates the Expression of miR-126 in Apolipoprotein E-knockout Mice with Carotid Atherosclerotic Plaque

Cellular and Molecular Neurobiology
Xudong PanXing Xiao

Abstract

Carotid atherosclerosis (AS) is a chronic inflammatory disease of the carotid arterial wall, which is very important in terms of the occurrence of cerebral vascular accidents. Studies have demonstrated that microRNAs (miRNAs) and their target genes are involved in the formation of atherosclerosis and that atorvastatin might reduce atherosclerotic plaques by regulating the expression of miRNAs. However, the related mechanism is not yet known. In this study, we first investigated the effects of atorvastatin on miR-126 and its target gene, i.e., vascular cell adhesion molecule-1 (VCAM-1) in apolipoprotein E-knockout (ApoE-/-) mice with carotid atherosclerotic plaque in vivo. We compared the expressions of miR-126 and VCAM-1 between the control, atherosclerotic model and atorvastatin treatment groups of ApoE-/- mice using RT-PCR and Western blot. We found the miR-126 expression was significantly down-regulated, and the VCAM-1 expression was significantly up-regulated in the atherosclerotic model group, which accelerated the progression of atherosclerosis in the ApoE-/- mice. These results following atorvastatin treatment indicated that miR-126 expression was significantly up-regulated, VCAM-1 expression was significantly down-regul...Continue Reading

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Citations

Mar 13, 2018·British Journal of Haematology·Rima S ZahrDavid R Archer
Aug 28, 2020·European Journal of Clinical Investigation·Nooshin MohammadzadehAmirhossein Sahebkar
Dec 13, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·John HungAndrew H Baker
Mar 12, 2021·The Journal of Obstetrics and Gynaecology Research·Beibei LiuTiantian Wang
Jun 21, 2020·Experimental Neurology·Yu QianJieli Chen

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Pro
Image J
SPSS
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