Atorvastatin Use Associated With Acute Pancreatitis: A Case-Control Study in Taiwan

Medicine
Shih-Wei LaiKuan-Fu Liao

Abstract

Few data are present in the literature on the relationship between atorvastatin use and acute pancreatitis. The aim of this study was to explore this issue in Taiwan. Using representative claims data established from the Taiwan National Health Insurance Program, this case-control study consisted of 5810 cases aged 20 to 84 years with a first-time diagnosis of acute pancreatitis during the period 1998 to 2011and 5733 randomly selected controls without acute pancreatitis. Both cases and controls were matched by sex, age, comorbidities, and index year of diagnosing acute pancreatitis. Subjects who at least received 1 prescription for other statins or nonstatin lipid-lowering drugs were excluded from the study. If subjects never had 1 prescription for atorvastatin, they were defined as never use of atorvastatin. Current use of atorvastatin was defined as subjects whose last remaining 1 tablet of atorvastatin was noted ≤7 days before the date of diagnosing acute pancreatitis. Late use of atorvastatin was defined as subjects whose last remaining 1 tablet of atorvastatin was noted >7 days before the date of diagnosing acute pancreatitis. The odds ratio with 95% confidence interval of acute pancreatitis associated with atorvastatin use...Continue Reading

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Citations

Mar 17, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Livia Archibugi, Gabriele Capurso
Nov 3, 2017·Journal of Clinical Gastroenterology·Peter J LeeTyler Stevens
Jan 9, 2018·European Journal of Gastroenterology & Hepatology·Ulrich C BangFlemming Bendtsen
Mar 1, 2017·European Journal of Hospital Pharmacy. Science and Practice·Shih-Wei LaiKuan-Fu Liao
Mar 17, 2017·Journal of Clinical Pharmacology·Chih-Ming LinShih-Wei Lai
Oct 6, 2018·United European Gastroenterology Journal·Goran PoropatGabriele Capurso
Nov 19, 2020·Canadian Journal of Gastroenterology & Hepatology·Ann-Lorie GagnonKarine Tremblay

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