Atorvastatin Versus Placebo for Prostate Cancer Before Radical Prostatectomy-A Randomized, Double-blind, Placebo-controlled Clinical Trial.

European Urology
Teemu J MurtolaTeuvo L J Tammela

Abstract

We tested whether intervention with atorvastatin affects the prostate beneficially compared with placebo in men with prostate cancer in a randomized clinical trial. A total of 160 statin-naïve prostate cancer patients scheduled for radical prostatectomy were randomized to use 80mg atorvastatin or placebo daily from recruitment to surgery for a median of 27 d. Blinding was maintained throughout the trial. In total, 158 men completed the follow-up, with 96% compliance. Overall, atorvastatin did not significantly lower tumor proliferation index Ki-67 or serum prostate-specific antigen (PSA) compared with placebo. In subgroup analyses, after a minimum of 28 d of atorvastatin use, Ki-67 was 14.1% lower compared with placebo (p = 0.056). Among high-grade cases (International Society of Urological Pathology Gleason grade 3 or higher), atorvastatin lowered PSA compared with placebo: median change -0.6 ng/ml; p = 0.024. Intraprostatic inflammation did not differ between the study arms (p = 0.8). Despite a negative overall result showing no effect of statins on Ki67 or PSA overall, in post hoc exploratory analyses, there appeared to be benefit after a minimum duration of 28 d. Further studies are needed to verify this. PATIENT SUMMARY: C...Continue Reading

Citations

Mar 22, 2019·The Cancer Journal·Wenxin Xu, Glenn J Bubley
Jun 25, 2019·The Prostate·Emma KnuuttilaTeemu J Murtola
Mar 24, 2020·Prostate Cancer and Prostatic Diseases·Joseph LongoLinda Z Penn
Nov 23, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emma H AllottLorelei A Mucci
Sep 6, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph LongoLinda Z Penn
Feb 11, 2021·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Allan AverySangeet Ghai
Mar 31, 2021·Prostate Cancer and Prostatic Diseases·Emma H AllottKonrad H Stopsack
Jun 11, 2021·Frontiers in Oncology·Isabella GiacominiVeronica Cocetta
Jun 16, 2021·Biochemical Pharmacology·Kush K Patel, Khosrow Kashfi
May 21, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·In Gab JeongChoung-Soo Kim
Jul 21, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Teemu J Murtola, Aino Siltari
Nov 25, 2021·JAMA Oncology·Arla VettenrantaAnssi Auvinen

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