Atorvastatin

Expert Opinion on Pharmacotherapy
A S Wierzbicki

Abstract

Atorvastatin (Lipitor, Pfizer) is a safe and effective 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitor (statin). It is the most potent currently available statin in terms of lowering low-density lipoprotein (LDL) and total cholesterol levels. It was the first statin shown to lower triglycerides in patients with isolated hypertriglyceridaemia. It has a good safety profile. In common with other statins, it has non-lipid-lowering effects including improving endothelial function, antiproliferative actions on smooth muscle and reducing platelet aggregation. It also has anti-inflammatory effects and may reduce plasma glucose levels. Clinical trial evidence with this statin is currently limited. It did slightly reduce events in the AVERT trial comparing patients receiving coronary angioplasty with those receiving high-dose atorvastatin therapy and in the MIRACL study reduced ischemia in patients with acute coronary syndromes. Other end point trials are in progress.

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Citations

Feb 17, 2010·Clinical Drug Investigation·Manuela MerliDomenico Alvaro
Oct 5, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nanette C Schloot, Irun R Cohen
Oct 27, 2004·Expert Opinion on Investigational Drugs·Anthony S Wierzbicki
Feb 3, 2005·Bioorganic & Medicinal Chemistry Letters·José Luis Medina-FrancoJoaquín Tamariz
Sep 27, 2008·Acta Pharmacologica Sinica·Jing DongGuang-ji Wang
Feb 8, 2019·Canadian Journal of Physiology and Pharmacology·Deniz Kaleli-DurmanB Sönmez Uydeş-Doğan
Nov 8, 2007·The Journal of Pharmacology and Experimental Therapeutics·Cort S MadsenPhilip D Stein
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Farhad R Danesh, Yashpal S Kanwar
Jul 2, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L Rodríguez-PáezC Wong

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