Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Daniel CamusInternational Malarone Study Team

Abstract

Atovaquone-proguanil has been shown to be effective and well tolerated for malaria prophylaxis in residents of countries of endemicity and in nonimmune adult travelers, but data about traveling children are limited. In a randomized, open-label, multicenter prophylaxis trial, 221 nonimmune pediatric travelers (age, 2-17 years) received either atovaquone-proguanil or chloroquine-proguanil. Safety and clinical outcome were evaluated 7, 28, and 60 days after travel. By posttravel day 7, a total of 39 (35%) of 110 atovaquone-proguanil and 41 (37%) of 111 chloroquine-proguanil recipients reported > or =1 adverse event. The data indicate that, over the course of treatment, fewer atovaquone-proguanil recipients had treatment-related adverse events (8% vs. 14%), including gastrointestinal complaints (5% vs. 10%). Two subjects discontinued prophylaxis because of drug-related adverse events; both had received chloroquine-proguanil. Observed compliance with prophylaxis was similar before and during travel, but it was higher for atovaquone-proguanil in the posttravel period. No study participant developed malaria. Atovaquone-proguanil was well tolerated and is an important addition to the limited arsenal of prophylactic agents available to ...Continue Reading

References

Mar 4, 1998·Tropical Medicine & International Health : TM & IH·R BwireW M Docters van Leeuwen
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G D ShanksT R Scott
Feb 3, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·S M GreenW Garrett
Apr 8, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H D NothdurftT Löscher
Aug 4, 1999·The American Journal of Tropical Medicine and Hygiene·C Weijer
Jun 8, 2000·The New England Journal of Medicine·E T Ryan, K C Kain
Sep 9, 2000·Archives of Internal Medicine·G DorseyP J Rosenthal
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K C KainJ S Keystone
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D OverboschUNKNOWN Malarone International Study Team
Nov 13, 2001·Journal of Travel Medicine·H O LobelP Waiyaki
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith LingUNKNOWN Naval Medical Research Unit 2 Clinical Trial Team
Nov 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-François FaucherPeter G Kremsner

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Citations

Sep 14, 2006·JAMA : the Journal of the American Medical Association·Daniel K BenjaminJennifer S Li
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R HillUNKNOWN Infectious Diseases Society of America
Oct 30, 2010·Malaria Journal·Gini G C van RijckevorselAnneke van den Hoek
Dec 20, 2012·The American Journal of Tropical Medicine and Hygiene·John E GimnigM Nabie Bayoh
Jul 20, 2010·Journal of Travel Medicine·John C DePetrilloMiriam A Smith
Jun 24, 2016·Malaria Journal·Remington L Nevin, Ashley M Croft
Feb 28, 2006·The Lancet Infectious Diseases·Carlos Franco-Paredes, José Ignacio Santos-Preciado
Apr 6, 2019·JAMA Network Open·Eric KendjoUNKNOWN French Imported Malaria Study Group
Feb 25, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alan M HochbergStephanie J Reisinger
Nov 19, 2020·Patient Preference and Adherence·Chaturaka RodrigoSumadhya Deepika Fernando

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