PMID: 11931723Apr 5, 2002Paper

ATP-binding cassette (ABC) transporters in atherosclerosis

Current Atherosclerosis Reports
G Schmitz, Wolfgang E Kaminski

Abstract

Macrophages play a central role in the initiation and progression of atherosclerotic lesions. In the nascent lesion, macrophages transform into foam cells through the excessive accumulation of cholesteryl esters. Dysfunctional lipid homeostasis in macrophages and foam cells ultimately results in the breakdown of membrane integrity and cell death. Studies within the past 2 years have implicated a defined subset of multispan transmembrane proteins, the ATP-binding cassette (ABC) transporters, in macrophage lipid homeostasis. The recent finding that ABCA1, beyond its function as a major regulator of plasma high-density lipoprotein metabolism, exerts significant antiatherosclerotic activities has provided the first direct evidence for the role of an ABC transporter in the pathogenesis of atherosclerosis.

References

Jan 1, 1992·Annual Review of Cell Biology·C F Higgins
Apr 1, 1974·The Journal of Clinical Investigation·A K Bhattacharyya, W E Connor
May 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·G RoglerG Schmitz
May 3, 1996·Science·J L Breslow
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J KartenbeckD Keppler
Dec 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·G RotheG Schmitz
Feb 1, 1997·Nature Genetics·A Decottignies, A Goffeau
May 23, 1998·The Journal of Biological Chemistry·T GerloffP J Meier
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jan 27, 1999·Atherosclerosis·A J Brown, W Jessup
Mar 6, 1999·The Journal of Biological Chemistry·G D LukerD Piwnica-Worms
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A T RemaleyH B Brewer
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J KluckenG Schmitz
Mar 22, 2000·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·G SchmitzW Drobnik
May 9, 2000·Biochemical and Biophysical Research Communications·C R PullingerJ P Kane
Jun 20, 2000·The Journal of Biological Chemistry·P CostetA R Tall
Jun 30, 2000·Biochemical and Biophysical Research Communications·W E KaminskiG Schmitz
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·S Santamarina-FojoH B Brewer
Oct 12, 2000·Cellular Signalling·T MatozakiY Takai
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·A VenkateswaranP Tontonoz
Oct 26, 2000·Current Opinion in Lipidology·G SchmitzE Orsó
Oct 26, 2000·Current Opinion in Lipidology·Y V Bobryshev

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Citations

Feb 27, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Javier Delgado-ListaJose Lopez-Miranda
Nov 29, 2011·Molecular Nutrition & Food Research·Antonio Garcia-RiosFrancisco Perez-Jimenez
Jun 19, 2013·Journal of Lipid Research·Mano R MauryaShankar Subramaniam
Jun 26, 2004·The Journal of Biological Chemistry·Stein RoosbeekMaryvonne Rosseneu
Nov 28, 2002·Annals of Medicine·Gerd Schmitz, Christa Buechler
Sep 23, 2003·Current Opinion in Lipidology·Trevor D Littlewood, Martin R Bennett

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