ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion

Blood
Nathalie BlesDidier Communi

Abstract

ATP, which has an important proinflammatory action as danger signal, induces the semimaturation of dendritic cells (DCs) that can be associated with immune tolerance. We identified epidermal growth factor receptor ligands as target genes of ATPγS, a slowly hydrolyzed ATP derivative, by a gene profiling approach in DCs. Amphiregulin was the most highly up-regulated gene in response to ATPγS. Human monocyte-derived DCs and mouse bone marrow-derived DCs released amphiregulin (AREG) after purinergic receptor activation, with a contribution of P2Y(11) and A(2B) receptor, respectively. Supernatants of LPS+ATPγS-stimulated DCs induced smooth muscle cell and Lewis Lung Carcinoma (LLC) cell growth in vitro. The coinjection of LPS+ATPγS-stimulated DCs or their supernatants with LLC cells increased tumor weight in mice compared with LPS-treated DCs. The preincubation of LPS+ATPγS-treated DC supernatants with an anti-AREG blocking antibody inhibited their positive effect on smooth muscle cell density and tumor growth. The present study demonstrates for the first time that DCs can be a source of AREG. ATP released from tumor cells might exert a tumorigenic action by stimulating the secretion of AREG from DCs. Antagonists of purinergic recep...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ShoyabG J Todaro
Aug 15, 1994·Biochemical and Biophysical Research Communications·M S KobrinM Korc
Aug 1, 1993·Japanese Journal of Cancer Research : Gann·Y KitadaiE Tahara
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A la SalaG Girolomoni
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F WilkinB Robaye
Nov 2, 2002·Blood·Muneo NumasakiMichael T Lotze
Feb 19, 2003·Biochemical and Biophysical Research Communications·Masayuki KatoIsamu Miyamori
Oct 11, 2003·Current Drug Targets·Dmitry Gabrilovich, Vladimir Pisarev
Mar 3, 2004·The Journal of Cell Biology·Umut SahinCarl P Blobel
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Sylvie DesruisseauYolande Berthois
Aug 18, 2004·Cancer Research·Tyler J CurielWeiping Zou
Dec 2, 2004·Nature Reviews. Immunology·Dmitry Gabrilovich
Mar 24, 2005·British Journal of Cancer·G CoukosJ R Conejo-Garcia
Jul 28, 2005·Cellular Immunology·Neil E HubbardKent L Erickson
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elena RiboldiSilvano Sozzani
Apr 14, 2006·Cancer Treatment and Research·Theresa L Whiteside
Nov 7, 2006·Cancer Immunology, Immunotherapy : CII·Kousaku MimuraHideki Fujii
Feb 27, 2007·Cancer Letters·C BerasainM A Avila
Aug 19, 2007·Trends in Pharmacological Sciences·Francesco Di Virgilio
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie BlesDidier Communi
May 10, 2008·European Journal of Immunology·Abduelhakem Ben AddiBernard Robaye
May 13, 2008·Journal of Mammary Gland Biology and Neoplasia·Mark D Sternlicht, Susan W Sunnarborg
Jun 19, 2008·Blood·Sergey V NovitskiyMikhail M Dikov
Nov 11, 2008·Nature·Joshua I GreenbergDavid A Cheresh
Apr 7, 2009·Purinergic Signalling·Nicholas WhiteGeoffrey Burnstock
Jun 12, 2009·International Archives of Allergy and Immunology·Kenji MatsumotoHirohisa Saito

❮ Previous
Next ❯

Citations

Jan 28, 2014·Seminars in Cell & Developmental Biology·Carmen Berasain, Matías A Avila
Oct 14, 2010·Seminars in Immunopathology·Benjamin Frey, Udo S Gaipl
Nov 26, 2015·Current Opinion in Immunology·Philippe NaquetFranck Galland
Sep 15, 2015·Biochemical and Biophysical Research Communications·Chen MengYounian Xu
Oct 30, 2014·Purinergic Signalling·Geoffrey Burnstock, Jean-Marie Boeynaems
May 18, 2016·Cellular and Molecular Life Sciences : CMLS·Aleta Pupovac, Ronald Sluyter
Mar 16, 2018·Mediators of Inflammation·Marta Stolarczyk, Bob J Scholte
Jun 20, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhenlong LiWenzheng Jiang
Jun 20, 2020·Journal of Leukocyte Biology·Mariana M S Oliveira, Lisa S Westerberg
Jun 9, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Margherita SistoSabrina Lisi
May 22, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lin DingSem H Phan
Jul 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ya-Ling HsuPo-Lin Kuo
Nov 20, 2020·International Journal of Molecular Sciences·Kijeong LeeTae Hoon Kim
Nov 25, 2020·Biochemical Pharmacology·Didier CommuniJean-Marie Boeynaems
Oct 27, 2021·Journal of Cellular Physiology·Siddharth S SinghRajiv Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Michiyo YamadaHiroshi Shimada
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Toshiaki WatanabeHirokazu Nagawa
Proceedings of the National Academy of Sciences of the United States of America
J DongH S Wiley
© 2021 Meta ULC. All rights reserved