ATP drives lamina propria T(H)17 cell differentiation

Nature
Koji AtarashiKiyoshi Takeda

Abstract

Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we show that adenosine 5'-triphosphate (ATP) that can be derived from commensal bacteria activates a unique subset of lamina propria cells, CD70(high)CD11c(low) cells, leading to the differentiation of T(H)17 cells. Germ-free mice exhibit much lower concentrations of luminal ATP, accompanied by fewer lamina propria T(H)17 cells, compared to specific-pathogen-free mice. Systemic or rectal administration of ATP into these germ-free mice results in a marked increase in the number of lamina propria T(H)17 cells. A CD70(high)CD11c(low) subset of the lamina propria cells expresses T(H)17-prone molecules, such as IL-6, IL-23p19 and transforming-growth-factor-beta-activating integrin-alphaV and -beta8, in response to ATP stimulation, and preferentially induces T(H)17 differentiation of co-cultured naive CD4(+) T cells. The critical role of ATP is further underscored by the observation that administration of ATP exacerbates a T-cell-mediated colitis model with ...Continue Reading

References

Sep 25, 2002·Physiological Reviews·R Alan North
Jan 4, 2003·Nature Reviews. Immunology·Sidonia Fagarasan, Tasuku Honjo
Jul 10, 2003·Gastroenterology·Emiko MizoguchiAtsushi Mizoguchi
Jan 18, 2005·Science·Jan Hendrik NiessHans-Christian Reinecker
May 23, 2006·Nature Immunology·Daniel J Cua, Robert A Kastelein
Aug 4, 2006·Nature·Baljit S Khakh, R Alan North
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
Jan 5, 2007·Annual Review of Immunology·Casey T WeaverLaurie E Harrington
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
Mar 24, 2007·Annual Review of Immunology·Akiko Iwasaki
Oct 9, 2007·Gastroenterology·Judy H Cho, Casey T Weaver
Nov 28, 2007·The Journal of Experimental Medicine·Lisa C ZabaJames G Krueger
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sun-Young ChangMi-Na Kweon
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper

❮ Previous
Next ❯

Citations

Mar 3, 2009·Inflammatory Bowel Diseases·Clara Abraham, Judy Cho
Mar 12, 2010·Inflammatory Bowel Diseases·Massimiliano SarraGiovanni Monteleone
Aug 31, 2010·Inflammatory Bowel Diseases·Elke Cario
Aug 20, 2010·Inflammatory Bowel Diseases·Sabine M IvisonTheodore S Steiner
Oct 14, 2011·Inflammatory Bowel Diseases·J VerdierF M Ruemmele
Feb 24, 2012·Inflammatory Bowel Diseases·Atsushi Mizoguchi
Mar 30, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Johannes StephaniJan Hendrik Niess
May 17, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Robert ZeiserMarco Idzko
Jan 29, 2010·Seminars in Immunopathology·Keiji HirotaMarc Veldhoen
Feb 11, 2012·Acta Neuropathologica·Kerstin Berer, Gurumoorthy Krishnamoorthy
Sep 9, 2010·Cell and Tissue Research·Patrick N Fries, Philip J Griebel
Apr 29, 2010·Current Allergy and Asthma Reports·Jun Kunisawa, Hiroshi Kiyono
Apr 12, 2011·Immunologic Research·Ioannis DrygiannakisIan J Glomski
Sep 10, 2013·Cytokine·Chunfang GuXiaoxia Li
Mar 13, 2013·Trends in Immunology·Ehud Zigmond, Steffen Jung
Jul 31, 2013·Journal of Autoimmunity·Palak J Trivedi, David H Adams
Jan 21, 2012·The British Journal of Nutrition·Linda V Thomas, Theo Ockhuizen
May 15, 2009·Expert Reviews in Molecular Medicine·Sigrid E M Heinsbroek, Siamon Gordon
Aug 17, 2010·Acta Pharmacologica Sinica·Lin MeiQi-bing Mei
Apr 13, 2010·Cellular & Molecular Immunology·Sheng Xu, Xuetao Cao
Mar 4, 2009·Cell Research·Alexandre S BassoDaniel Mucida
Feb 13, 2013·Immunology and Cell Biology·Julia FaracheSteffen Jung
Jan 16, 2013·Immunology and Cell Biology·Yoshiyuki Goto, Ivaylo I Ivanov
Nov 6, 2009·Mucosal Immunology·E C LavelleE M Creagh
Feb 12, 2010·Mucosal Immunology·I I Ivanov, D R Littman
May 24, 2012·Mucosal Immunology·N BouladouxY Belkaid
Mar 22, 2013·Mucosal Immunology·M Fukata, M Arditi
Jun 17, 2011·Nature·Andrew L KauJeffrey I Gordon
Sep 14, 2012·Nature·Craig L MaynardCasey T Weaver
Sep 6, 2012·Nature Communications·Yosuke KurashimaHiroshi Kiyono
Feb 7, 2013·Nature Communications·Teruaki NakatsujiRichard L Gallo
Dec 18, 2009·Nature Immunology·Matthew T Palmer, Casey T Weaver
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Jan 19, 2010·Nature Reviews. Immunology·John E Sims, Dirk E Smith
May 26, 2010·Nature Reviews. Immunology·Chen VarolSteffen Jung
Sep 11, 2010·Nature Reviews. Immunology·Akiko Iwasaki
Sep 25, 2010·Nature Reviews. Immunology·Nadine Cerf-Bensussan, Valérie Gaboriau-Routhiau
Nov 15, 2011·Nature Reviews. Immunology·Julien RoyetRoman Dziarski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.