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ATP hydrolysis by the SNF2 domain of the ultraspecific maintenance methylase Dnmt5 drives recognition and modification of hemimethylated DNA

bioRxiv

Jan 6, 2020

Phillip A. DumesicHiten Madhani

Abstract

C. neoformans Dnmt5 is an ultraspecific maintenance-type CpG methyltransferase (DNMT) that mediates long-term epigenome evolution. It harbors a DNMT domain and SNF2 ATPase domain. We find that the SNF2 domain couples substrate specificity to an ATPase step that is essential for DNA meth...read more

Mentioned in this Paper

Brodmann Area
CXXC1 gene
Finding
DNA Methylation
Cytosine
Nucleosome Location
DNMT1
SMARCA4 protein, human
CpG Islands
Methyl CpG Binding Domain
16
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ATP hydrolysis by the SNF2 domain of the ultraspecific maintenance methylase Dnmt5 drives recognition and modification of hemimethylated DNA

bioRxiv

Jan 6, 2020

Phillip A. DumesicHiten Madhani

DOI: 10.1101/2020.01.05.895227

Abstract

C. neoformans Dnmt5 is an ultraspecific maintenance-type CpG methyltransferase (DNMT) that mediates long-term epigenome evolution. It harbors a DNMT domain and SNF2 ATPase domain. We find that the SNF2 domain couples substrate specificity to an ATPase step that is essential for DNA meth...read more

Mentioned in this Paper

Brodmann Area
CXXC1 gene
Finding
DNA Methylation
Cytosine
Nucleosome Location
DNMT1
SMARCA4 protein, human
CpG Islands
Methyl CpG Binding Domain
16

Similar Papers Found In These Feeds

DNA Methylation

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Phase-Separation and Heterochromatin(Keystone)

Heterochromatin is condensed chromatin that was previously believed to be inaccessible for transcription, although this has been disproven. Heterochromatin plays a role in gene expression. This feed looks specifically at the role of phase-separation in heterochromatin; follow this feed to stay up to date on this topic.

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