ATP receptors in pain sensation: Involvement of spinal microglia and P2X(4) receptors.

Purinergic Signalling
Kazuhide InoueSchuichi Koizumi

Abstract

There is abundant evidence that extracellular ATP and other nucleotides have an important role in pain signaling at both the periphery and in the CNS. At first, it was thought that ATP was simply involved in acute pain, since ATP is released from damaged cells and excites directly primary sensory neurons by activating their receptors. However, neither blocking P2X/Y receptors pharmacologically nor suppressing the expression of P2X/Y receptors molecularly in sensory neurons or in the spinal cord had an effect on acute physiological pain. The focus of attention now is on the possibility that endogenous ATP and its receptor system might be activated in pathological pain states, particularly in neuropathic pain. Neuropathic pain is often a consequence of nerve injury through surgery, bone compression, diabetes or infection. This type of pain can be so severe that even light touching can be intensely painful; unfortunately, this state is generally resistant to currently available treatments. An important advance in our understanding of the mechanisms involved in neuropathic pain has been made by a recent work demonstrating the crucial role of ATP receptors (i.e., P2X(3) and P2X(4) receptors). In this review, we summarize the role of...Continue Reading

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Citations

May 28, 2014·The Journal of General Physiology·Batu Keceli, Yoshihiro Kubo
Dec 6, 2011·Molecular Pain·Jeannine C FoleyPhilip G Haydon
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Sep 8, 2009·The Journal of Pain : Official Journal of the American Pain Society·André P SchmidtDiogo O Souza

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Methods Mentioned

BETA
antisense oligodeoxynucleotide

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