ATP release after partial hepatectomy regulates liver regeneration in the rat.

Journal of Hepatology
Emmanuel GonzalesThierry Tordjmann

Abstract

Paracrine interactions are critical to liver physiology, particularly during regeneration, although physiological involvement of extracellular ATP, a crucial intercellular messenger, remains unclear. The physiological release of ATP into extracellular milieu and its impact on regeneration after partial hepatectomy were investigated in this study. Hepatic ATP release after hepatectomy was examined in the rat and in human living donors for liver transplantation. Quinacrine was used for in vivo staining of ATP-enriched compartments in rat liver sections and isolated hepatocytes. Rats were treated with an antagonist for purinergic receptors (Phosphate-6-azo(benzene-2,4-disulfonic acid), PPADS), and liver regeneration after hepatectomy was analyzed. A robust and transient ATP release due to acute portal hyperpressure was observed immediately after hepatectomy in rats and humans. Clodronate liposomal pre-treatment partly inhibited ATP release in rats. Quinacrine-stained vesicles, co-labeled with a lysosomal marker in liver sections and isolated hepatocytes, were predominantly detected in periportal areas. These vesicles significantly disappeared after hepatectomy, in parallel with a decrease in liver ATP content. PPADS treatment inhi...Continue Reading

References

Jan 1, 1984·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J F Ngala KendaL Lambotte
Oct 21, 1998·The Journal of General Virology·C FournierP Maurel
May 18, 1999·Canadian Journal of Physiology and Pharmacology·H H Wang, W W Lautt
Aug 22, 2000·Journal of Hepatology·A P FeranchakR M Roman
Jan 15, 2002·American Journal of Physiology. Renal Physiology·G E KnightG Burnstock
Apr 18, 2003·Luminescence : the Journal of Biological and Chemical Luminescence·Mark W GormanEric O Feigl
Sep 2, 2003·Biochimica Et Biophysica Acta·Erik M Schwiebert, Akos Zsembery
Oct 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexandra NicouThierry Tordjmann
Nov 8, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·David GatofJ Gregory Fitz
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sundararajah ThevanantherSaul J Karpen
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Rebecca Taub
Oct 27, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Akihiro HirataMasae Tatematsu
Apr 14, 2006·Histochemistry and Cell Biology·Zhenghua XiangGeoffrey Burnstock
Jun 29, 2007·FEBS Letters·Emmanuel GonzalesLaurent Combettes
Jul 10, 2007·Nature Cell Biology·Zhijun ZhangShumin Duan
Aug 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sara CrummJan B Hoek

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Citations

Feb 9, 2012·Langenbeck's Archives of Surgery·Kerstin AbshagenBrigitte Vollmar
Dec 25, 2012·Journal of Molecular Histology·Seo Jin LeeJunyang Jung
Jul 16, 2013·Cell Death and Differentiation·I MartinsG Kroemer
Feb 22, 2013·Current Opinion in Organ Transplantation·Andrew W Duncan, Alejandro Soto-Gutierrez
Dec 3, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michel FaustherJean Sévigny
Nov 3, 2012·International Journal of Hepatology·Isabelle Garcin, Thierry Tordjmann
Nov 26, 2013·Purinergic Signalling·Geoffrey BurnstockSimon C Robson
Dec 10, 2013·Antioxidants & Redox Signaling·Rowan F van GolenMichal Heger
May 9, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chunjiong WangYoufei Guan
May 23, 2012·Cytokine & Growth Factor Reviews·Rowan F van GolenMichal Heger
May 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Noémie PéanThierry Tordjmann
Oct 13, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoya IkedaNobuhiro Ohkohchi
Nov 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sundararajah Thevananther
Feb 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aurore BesnardThierry Tordjmann
Jun 5, 2012·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Michel FaustherJonathan A Dranoff
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laura LagoudakisThierry Tordjmann
Aug 18, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nadine GraubardtGuido Beldi
Jul 13, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yu Mei, Sundararajah Thevananther
May 18, 2013·European Journal of Immunology·Mingming FangYong Xu
Mar 30, 2016·Clinical Therapeutics·Franco PandolfiPio Conti
Sep 9, 2015·Frontiers in Immunology·Emilie VénéreauMarco Emilio Bianchi
Dec 15, 2012·Biochemical and Biophysical Research Communications·Junyang JungHiroshi Kiyama
Feb 9, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ramesh KudiraGuido Beldi
Jun 16, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aurore BesnardThierry Tordjmann
Mar 24, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R ZeiserG Burnstock
Mar 18, 2017·Molecular Aspects of Medicine·Grégory MerlenThierry Tordjmann
Dec 14, 2017·Nature Communications·Lucía Barbier-TorresMaría Luz Martínez-Chantar
Jul 28, 2010·Oncogene·J Stagg, M J Smyth
Oct 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tanaporn KhamphayaJittima Weerachayaphorn
May 27, 2020·Médecine sciences : M/S·Amelle ChouiterOlivier Dellis
Sep 10, 2014·Purinergic Signalling·Jessica R GoreeJonathan A Dranoff
Dec 5, 2019·Frontiers in Immunology·Andrea Kristina HorstLinda Diehl
Mar 20, 2020·Oxidative Medicine and Cellular Longevity·Chang Xian LiXiang Cheng Li
Jun 7, 2019·Hepatology Communications·Adrien Guillot, Frank Tacke
Jul 3, 2019·Journal of Cellular Biochemistry·Jiarui ChenJun Yang
Oct 11, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bryan C TackettSundararajah Thevananther
Oct 21, 2016·Médecine sciences : M/S·Anthony Lambert, Boris Julien
Feb 22, 2018·Physiological Reviews·Maysa SarhanAndreas Linkermann
Mar 9, 2011·Médecine sciences : M/S·Laurent Combettes, Geneviève Dupont
Jun 29, 2017·Inflammation·Tatsuya AndoMitsuru Seishima

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