PMID: 9550294Apr 29, 1998Paper

ATP release caused by bradykinin, substance P and histamine from intact and cultured smooth muscles of guinea-pig vas deferens

Naunyn-Schmiedeberg's Archives of Pharmacology
S TamesueTakeshi Katsuragi

Abstract

Histamine (60 microM) produced ATP release from segments of guinea-pig vas deferens which was blocked by pyrilamine and triprolidine, H1-blockers, but not by ranitidine, an H2-blocker. The evoked-release was inhibited by the mitochondrial inhibitors, carbonyl cyanide-m-chlorophenylhydrazone (CCCP) and oligomycin. Bradykinin (BK) and substance P (SP) also caused substantial and moderate release of ATP, respectively. The BK-evoked release of ATP was inhibited by HOE140, a B2-antagonist, but not by [Des-Arg10] HOE140, a B1-antagonist. On the other hand, VIP, angiotensin II (AII) and cholecystokinin-octapeptide (CCK-8) failed to elicit a measurable release of ATP. Histamine and BK also enhanced the release of ATP from superfused cultured smooth muscle cells. These results suggest that ATP may be released as an autacoid from the smooth muscles in the presence of these chemical mediators.

Citations

Feb 6, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Yumei ZhaoTakeshi Katsuragi
Sep 29, 2000·Pharmacology & Therapeutics·J Spychala
Feb 4, 2009·Autonomic Neuroscience : Basic & Clinical·Luis Eduardo M Quintas, François Noël
Apr 7, 2006·The Journal of Pharmacy and Pharmacology·Naoko TanakaKazumasa Shinozuka
Feb 15, 2005·Biochemical and Biophysical Research Communications·Keisuke MigitaTakeshi Katsuragi
Mar 3, 2007·Biochemical Pharmacology·Keisuke MigitaTakeshi Katsuragi
Jun 11, 2002·Biochemical and Biophysical Research Communications·Takeshi KatsuragiKenji Honda
Feb 26, 2015·Journal of Biochemistry·Sayo YashimaHideyoshi Higashi
Jun 1, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Takeshi Katsuragi, Keisuke Migita
Sep 11, 2007·Journal of Pharmacological Sciences·Yumei ZhaoTakeshi Katsuragi
Dec 21, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Juliana Maia TeixeiraCláudia Herrera Tambeli
May 16, 2001·American Journal of Physiology. Renal Physiology·E W Inscho
Dec 3, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Junzo Kamei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.