ATP release mechanisms, ATP receptors and purinergic signalling along the nephron

Clinical and Experimental Pharmacology & Physiology
E M Schwiebert

Abstract

1. Autocrine and paracrine signalling along the nephron of the kidney has been a widely held hypothesis for several decades. The lumen of the nephron is an ideal autocrine and paracrine signalling microenvironment. Any agonist, filtered at the glomerulus or released in the proximal tubule or other proximal segments, is subsequently trapped in the lumen of the nephron and present to interact with luminal receptors. Similar signalling in the renal interstitium is also possible and likely. Indeed, receptors for many autocrine and paracrine agonists have been characterized on the luminal membrane and serosal membrane of multiple nephron segments. 2. An important family of autocrine and paracrine agonists in the kidney are the purinergic agonists. Extracellular ATP, as well as its metabolites (ADP, 5'-AMP and adenosine), is released by renal epithelial cells. These compounds are also freely filtered at the glomerulus and are found in the final urine. Receptors for ATP and adenosine are also expressed on the luminal and serosal side of many nephron segments. 3. The present review discusses purinergic signalling by nucleotide agonists in an integrated manner, from ATP release to ATP receptors to extracellular ATP-mediated effects on r...Continue Reading

References

Nov 1, 1992·Journal of Cellular Physiology·D J WangL A Heppel
Oct 1, 1992·American Journal of Respiratory Cell and Molecular Biology·L B Wong, D B Yeates
Jan 15, 1986·The Biochemical Journal·J L Gordon
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y WangJ G Fitz
Oct 1, 1996·The European Journal of Neuroscience·G BuellF Rassendren
Jan 1, 1996·Annual Review of Cell and Developmental Biology·A J Brake, D Julius
Mar 6, 1998·The Journal of Laboratory and Clinical Medicine·M S PallerM E Rosenberg
May 22, 1998·General Pharmacology·D Erlinge
Jun 17, 1998·The Journal of Biological Chemistry·A P FeranchakJ G Fitz
Nov 14, 1998·The American Journal of Physiology·A L TaylorE M Schwiebert
Nov 17, 1998·Pflügers Archiv : European journal of physiology·A HazamaY Okada
Nov 26, 1998·Japanese Journal of Pharmacology·M P Abbracchio, G Burnstock
Dec 8, 1998·The Biochemical Journal·S P Kunapuli, J L Daniel
Jan 5, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N S MurciaE D Avner
Apr 13, 1999·The American Journal of Physiology·D C Devor, J M Pilewski
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·P D WilsonE M Schwiebert
Jul 22, 1999·Annals of the New York Academy of Sciences·A B MacKenzieR A North
Oct 8, 1999·The Journal of Clinical Investigation·A L TaylorE M Schwiebert
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·S W SchneiderJ P Geibel
Jul 27, 2000·American Journal of Physiology. Cell Physiology·H SauerM Wartenberg
May 8, 2001·Clinical and Experimental Pharmacology & Physiology·E W Inscho
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Lisa M SchwiebertErik M Schwiebert
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Phillip Darwin BellYasunobu Okada

❮ Previous
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Citations

May 30, 2006·Cellular and Molecular Life Sciences : CMLS·S D Roper
Apr 29, 2008·Purinergic Signalling·Michael B HovaterErik M Schwiebert
Mar 19, 2009·Purinergic Signalling·Edward W Inscho
Mar 31, 2009·Purinergic Signalling·P Darwin BellZhi-Ren Zhang
Mar 26, 2009·Purinergic Signalling·Bellamkonda K KishoreDonald E Kohan
Jun 10, 2009·Purinergic Signalling·Clare M TurnerFrederick W K Tam
Jun 26, 2003·Trends in Pharmacological Sciences·Astrid HoebertzGeoffrey Burnstock
May 8, 2001·Clinical and Experimental Pharmacology & Physiology·E W Inscho
Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Ho Jae HanJang Hern Lee
Feb 8, 2006·Annual Review of Physiology·Robert TarranRichard C Boucher
Jul 1, 2011·American Journal of Physiology. Renal Physiology·Volker Vallon, Timo Rieg
Nov 29, 2013·American Journal of Physiology. Renal Physiology·Guiping SuiChanghao Wu
Apr 23, 2010·American Journal of Physiology. Renal Physiology·Monu Goel, William P Schilling
Oct 3, 2008·American Journal of Physiology. Renal Physiology·Yue ZhangBellamkonda K Kishore
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Yue ZhangBellamkonda K Kishore
Apr 1, 2008·Nephron. Physiology·Scott S P Wildman, Brian F King
Jan 3, 2006·American Journal of Respiratory and Critical Care Medicine·Ian C DavisSadis Matalon
Mar 26, 2004·The Japanese Journal of Physiology·Ravshan Z Sabirov, Yasunobu Okada
Apr 20, 2014·Physiological Reports·Audrey J StoneHeidi A Kluess
Nov 23, 2013·Purinergic Signalling·Geoffrey BurnstockMatthew A Bailey
Jan 28, 2014·Pflügers Archiv : European journal of physiology·P GaillyO Devuyst
Dec 14, 2007·Kidney International·C Wagner
Jul 27, 2010·Life Sciences·Cristina Ribas FürstenauSusana Tchernin Wofchuk
Jul 1, 2008·Respiratory Physiology & Neurobiology·Brian ButtonUNKNOWN University of North Carolina Virtual Lung Group
Apr 17, 2004·Traffic·Gerard Apodaca
Nov 13, 2012·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Volker VallonTimo Rieg
Mar 3, 2007·Biochemical Pharmacology·Keisuke MigitaTakeshi Katsuragi
Jul 9, 2004·Respiratory Physiology & Neurobiology·Eric DubuisChristophe Vandier
Jun 9, 2016·Autonomic Neuroscience : Basic & Clinical·Geoffrey Burnstock, Andrzej Loesch
May 8, 2007·The Journal of Pain : Official Journal of the American Pain Society·Masamichi ShinodaYasuo Sugiura
Aug 13, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Glen P WestallPeter J Cowan
Mar 26, 2013·The International Journal of Biochemistry & Cell Biology·Jingqin FangWeiguo Zhang

❮ Previous
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