ATP-sensitive K+ channels mediate regulation of substance P release via the prejunctional histamine H3 receptor

European Journal of Pharmacology
T Ohkubo, M Shibata

Abstract

Perfusion of histamine (10(-3) M) elicited a significant increase of immunoreactive substance P release in the subcutaneous perfusate in the rat hindpaw. The active L-enantiomer of cromakalim, lemakalim (50 micrograms/kg, i.v.), a selective K+ channel activator, significantly inhibited the immunoreactive substance P release. Glibenclamide (10 mg/kg, i.v.), an ATP-sensitive K+ channel blocker, abolished the response to lemakalim on the release of immunoreactive substance P. R(-)-alpha-methylhistamine (1 mg/kg, i.v.), a specific histamine H3 receptor agonist, significantly inhibited the release of immunoreactive substance P. Glibenclamide (10 mg/kg, i.v.) antagonized the inhibitory effect of R(-)-alpha-methylhistamine. Tetraethylammonium (10 mg/kg, i.p.), a K+ channel blocker, also reduced the inhibitory effect significantly. These results suggest that the inhibition of substance P release from sensory nerve endings via prejunctional histamine H3 receptors may be achieved by activating the ATP-sensitive K+ channel coupled to the histamine H3 receptor in the rat skin.

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Citations

Jan 5, 2000·Journal of Neurochemistry·S MorissetJ C Schwartz
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y SugimotoC Kamei
Apr 11, 2006·Journal of Pharmacological Sciences·Maria Alejandra HossenChiaki Kamei
Jun 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alessandro PiniArianna Carolina Rosa
Jun 19, 2015·Pharmacological Reviews·Pertti PanulaHelmut L Haas
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Aug 14, 2020·Current Pharmaceutical Design·Augusto S Manzo AtencioManuel Velasco

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