PMID: 7012639Apr 2, 1981Paper

ATP-stimulated endoprotease is associated with the cell membrane of E. coli

Nature
R W Voellmy, A L Goldberg

Abstract

Despite knowledge of the physiological significance and regulation of protein degradation in bacteria, the pathway of proteolysis and the responsible enzymes are still not known. Degradation of cell proteins in bacterial and animal cells requires continuous ATP production, inhibition of which in Escherichia coli prevents the degradation of normal proteins in growing cells, accelerated breakdown of such proteins in starving cultures and the very rapid breakdown of abnormal proteins. Intracellular proteolysis proceeds by repeated endoproteolytic steps and ATP is required for the initial cleavages of the substrate. We have recently demonstrated ATP stimulation of proteolysis in extracts of bacterial and animal cells. These ATP-stimulated systems seem to be responsible for the rapid degradation of abnormal proteins in vivo, but they may also be involved in the catabolism of normal cell proteins, limited proteolysis, such as the processing of precursors for secreted or membrane proteins, and the selective inactivation of specific proteins, as occurs in the ATP-dependent cleavage of the lambda repressor by the recA protein. We report here that membrane fragments contain an ATP-stimulated protease that degrades cell proteins to large ...Continue Reading

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J D Etlinger, A L Goldberg
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·H Inouye, J Beckwith
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Citations

Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M F CharetteA Markovitz
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C H Chung, A L Goldberg
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L Waxman, A L Goldberg
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M Desautels, A L Goldberg
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B J HwangA L Goldberg
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C HermanP Bouloc
Feb 15, 1984·European Journal of Biochemistry·W SiemsS M Rapoport
Jul 5, 1982·FEBS Letters· Galperin MYuA N Glagolev
Aug 22, 2006·Journal of Structural Biology·David M SmithAlfred Goldberg
Jan 15, 1992·European Journal of Biochemistry·A L Goldberg
Jan 1, 1987·Journal of Basic Microbiology·M LudewigH Aurich
Jan 1, 1987·Journal of Basic Microbiology·B FrickeH Aurich
Sep 1, 1984·Microbiological Reviews·W J Ingledew, R K Poole

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