PMID: 9163327Apr 15, 1997Paper

ATP synthase subunit c expression: physiological regulation of the P1 and P2 genes

The Biochemical Journal
U AnderssonB Cannon

Abstract

Pre-translational regulation of subunit c has been suggested to control the biosynthesis of mitochondrial ATP synthase (ATPase) in brown adipose tissue (BAT). Subunit c is encoded by the genes P1 and P2, which encode identical mature proteins. We have determined here the levels of P1 and P2 mRNAs in different tissues, in response to cold acclimation in rats, during ontogenic development of BAT in hamsters, and following thyroid hormone treatment in rat BAT and liver. Quantitative ribonuclease protection analysis showed that both the P1 and P2 mRNAs were present in all rat tissues measured. Their total amount in each tissue corresponded well with the ATPase content of that tissue. While the P1/P2 mRNA ratio is high in ATPase-rich tissues, the P2 mRNA dominates in tissues with less ATPase. Cold acclimation affects P1 but not P2 gene expression in rat BAT. A rapid and transient increase in P1 mRNA is followed by sustained depression, which is accompanied by a decrease in ATPase content. Similarly, ontogenic suppression of ATPase content in hamster BAT was accompanied by suppression of the P1 mRNA levels, while P2 expression was virtually unchanged. Furthermore, when hypothyroid rats were treated with thyroid hormone, the steady-st...Continue Reading

Citations

May 3, 2008·Biological & Pharmaceutical Bulletin·Masahiro WatanabeYasuo Shinohara
Jan 29, 2011·Molecular Biology and Evolution·Michelle Déquard-ChablatVéronique Contamine
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shiro ItoiShugo Watabe
Aug 2, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tatiana V KramarovaBarbara Cannon
Dec 29, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Hela BahriStéphane Duvezin-Caubet
Jul 30, 2004·Biochimica Et Biophysica Acta·Josef HoustekJirí Zeman
May 30, 2006·Biochimica Et Biophysica Acta·Josef HoustekPavel Jesina
Jul 16, 2008·Biochimica Et Biophysica Acta·Roza KucharczykJean-Paul di Rago

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