PMID: 8595981Aug 1, 1995Paper

ATPase activity, IF1 content, and proton conductivity of ESMP from control and ischemic slow and fast heart-rate hearts

Journal of Bioenergetics and Biomembranes
W RouslinG Capozza

Abstract

Earlier studies by Rouslin and coworkers showed that, during myocardial ischemia in slow heart-rate species which include rabbits and all larger mammals examined including humans, there is an IF1-mediated inhibition of the mitochondrial ATPase due to an increase in the amount of IF1 bound to the ATPase (Rouslin, W., and Pullman, M.E., J. Mol. Cell. Cardiol. 19,661-668, 1987). Earlier work by Guerrieri and colleagues demonstrated that IF1 binding to bovine heart ESMP was accompanied by parallel decreases in ATPase activity and in passive proton conduction (Guerrieri, F., et al., FEBS Lett. 213, 67-72, 1987). In the present study rabbit was used as the slow heart-rate species and rat as the fast heart-rate species. Rat is a fast heart-rate species that contains too little IF1 to down regulate the ATPase activity present. Mitochondria were prepared from control and ischemic hearts and ESMP were made from aliquots by sonication at pH 8.0 with 2 mM EDTA. Oligomycin-sensitive ATPase activity and IF1 content were measured in SMP prepared from the control and ischemic mitochondrial samples. After identical incubation procedures, oligomycin-sensitive ATPase activity, oligomycin-sensitive proton conductivity, and IF1 content were also me...Continue Reading

References

Dec 1, 1978·European Journal of Biochemistry·A PansiniS Papa
Dec 1, 1991·Journal of Bioenergetics and Biomembranes·W Rouslin
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B FrangioneM E Pullman
Jul 1, 1994·Trends in Biochemical Sciences·R A CapaldiS Wilkens

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Citations

Mar 5, 2008·Antioxidants & Redox Signaling·Sachin A Gupte, Michael S Wolin
Nov 28, 2007·Annual Review of Pathology·Zheng DongManjeri A Venkatachalam
Jul 11, 2001·Journal of Molecular and Cellular Cardiology·E J LesnefskyC L Hoppel
Oct 21, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ivana MaticMichelangelo Campanella
Jun 30, 2009·Trends in Biochemical Sciences·Michelangelo CampanellaMichael R Duchen
Aug 19, 2008·The International Journal of Biochemistry & Cell Biology·Gary J GroverDonna Seto-Young
Sep 27, 2014·Critical Reviews in Toxicology·Robyn L PrueittJulie E Goodman
Jul 20, 2005·Biochimica Et Biophysica Acta·Heberty T F FacundoAlicia J Kowaltowski
Jul 2, 2008·Cell Metabolism·Michelangelo CampanellaMichael R Duchen
Apr 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Eiji Takahashi
Oct 8, 2009·Molecular and Cellular Biochemistry·Rama Surya Prakash PerepuRajat Sethi
Feb 12, 1998·The American Journal of Physiology·D W GreenG J Grover
Jun 6, 2000·Biochimica Et Biophysica Acta·D W Green, G J Grover
Mar 14, 2001·Biochimica Et Biophysica Acta·K YlitaloI Hassinen

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