PMID: 3754757Jan 1, 1986Paper

Atracurium infusion in the intensive care unit

British Journal of Anaesthesia
A J WadonS Anand

Abstract

An open study of 38 infusions of atracurium in 33 patients requiring neuromuscular blockade for ventilation was carried out. Consecutive patients requiring ventilation were studied and there were no exclusions. The initial rate of infusion was 0.4 mg kg-1 h-1 and this was adjusted according to clinical observation and the results of neuromuscular stimulation. The average infusion rate in the series was 0.59 mg kg-1 h-1. Patients were sedated using a morphine infusion at a rate of 2-4 mg kg-1 h-1. Satisfactory blockade was achieved in all cases. Time for spontaneous recovery following termination of infusion was recorded, the average recovery time being 39.2 min. Emphasis was placed on recording any possible serious toxic effects attributable to long-term atracurium infusions, possible toxic effects were considered and a satisfactory explanation of such effects was found in all cases.

Citations

Nov 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M D Sharpe
Jan 1, 1995·Paediatric Anaesthesia·R L Eyres
Jan 1, 1993·Intensive Care Medicine·J M Hunter
Aug 1, 1995·Critical Care Medicine·C A Manthous, W Chatila
Jun 18, 2005·Paediatric Anaesthesia·Francesca IodiceEnrico Bertini
Jan 1, 1994·Journal of Clinical Anesthesia·J Koska, L S Berman
Nov 1, 1988·Anaesthesia·S J PeatJ M Hunter
Apr 17, 2014·American Journal of Therapeutics·Rudrashish HaldarAnkush Singla
Jul 1, 1993·The Annals of Pharmacotherapy·K J KellyK Vance-Bryan

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