PMID: 3662995Jul 1, 1987

Atrial and ventricular myosins from human hearts. II. Isoenzyme distribution after myocardial infarction

Basic Research in Cardiology
U HoffmannN Palm


Human atrial and ventricular myosins were prepared from autopsy specimens from subjects with coronary heart disease. Cardiac myosin light chain isotypes were resolved using two-dimensional gel electrophoresis, whereas myosin isozymes were detected by pyrophosphate gel electrophoresis. Myocardial infarction and associated work overload cause a transition in the light chain complements of the myosins. Thus ventricular myosin light chains were found in pressure overloaded atria and atrial light chains have also been identified in the infarct ventricle of the human heart. Two molecular isoenzymes of the human atrial myosin, the relative proportions of which are changed after infarction, were separated under non-dissociating conditions by gel electrophoresis. A decrease in HA-3 and a corresponding increase in HA-1 were observed. Ventricular hypertrophy in patients with coronary insufficiency induces a second ventricle isomyosin, called HV-1, with the same electrophoretic mobility as HA-1. The relative part of this myosin type amounts to 20%. Comparative peptide mapping studies were carried out on myosin subfragment-1 preparations from normal and infarct ventricles. In the primary structures, the chymotrypsic digestions produced slig...Continue Reading


Jun 7, 1995·Molecular and Cellular Biochemistry·V PelouchM Samánek
Jan 1, 1992·IEEE Transactions on Bio-medical Engineering·H S Oster, Y Rudy
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·H SikorskaJ E van Lier
Dec 16, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·A BusatoC Gaillard


Dec 1, 1977·The Biochemical Journal·W Schwartz, J W Bird
Jun 1, 1978·Journal of Molecular and Cellular Cardiology·P A Poole-Wilson
Apr 29, 1975·Biochimica Et Biophysica Acta·C KlotzB Swynghedauw
May 30, 1975·Biochimica Et Biophysica Acta·K T ShiverickN R Alpert
Jan 30, 1976·European Journal of Clinical Investigation·J F LeclercqV Piguet
Jan 1, 1977·Journal of Molecular and Cellular Cardiology·A MalhotraJ Scheuer
Mar 1, 1977·Basic Research in Cardiology·B SwynghedauwJ J Leger
Aug 1, 1985·Journal of Molecular and Cellular Cardiology·C DechesneJ J Leger
May 1, 1985·Clinical and Experimental Pharmacology & Physiology·D F CatanzaroB J Morris
Dec 1, 1982·The Journal of Cell Biology·L GorzaS Schiaffino
Jul 1, 1983·Circulation Research·J J MercadierK Schwartz
Nov 1, 1983·Basic Research in Cardiology·S K Banerjee, J Wiener
Dec 1, 1981·European Journal of Biochemistry·H P PrinceC Turner
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V MahdaviB Nadal-Ginard
Jun 1, 1984·Journal of Molecular and Cellular Cardiology·P L KozlovskisR J Myerburg
Jan 1, 1981·The Journal of Cell Biology·S SartoreS Schiaffino
Nov 1, 1982·Basic Research in Cardiology·T SrihariM C Schaub

Related Concepts

Peptide Mapping
Complement System Proteins
Left Ventricular Structure
Myocardial Infarction
Right Atrial Structure
Immunoglobulin Isotypes
Coronary Arteriosclerosis
Coronary Artery Insufficiency

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.