Atrial fibrillation and risk of hip fracture: A population-based analysis of 113,600 individuals

International Journal of Cardiology
Christopher X WongPrashanthan Sanders

Abstract

A number of cardiovascular diseases have been linked with bone health and an increased risk of osteoporotic fracture. Whether atrial fibrillation (AF) is associated with subsequent fracture risk is not known. Administrative, clinical and hospitalisation information were linked over a 14-year period. From this longitudinal, population-based dataset of 113,600 individuals, time-dependent exposures using multivariate Cox proportional hazards regression models were employed to determine incidence rates and hazard ratios (HR) for hip fracture according to a history of AF. The annualised incidence rate for hip fracture was 7.4 per 1000 person-years (95% CI 7.1-7.7) in those without AF and 17.5 per 1000 person-years (95% CI 16.8-18.1) in those with AF. Compared to individuals without AF, those with AF were more likely to develop incident hip fracture in both men (unadjusted HR 2.39 [95% CI 1.96-2.91]) and women (unadjusted HR 2.91 [95% CI 2.55-3.34]). After adjusting for potential confounders, these associations were attenuated but remained statistically significant (adjusted HR 1.97 [95% CI 1.61-2.42] in men; adjusted HR 2.08 [95% CI 1.80-2.39] in women). A history of AF was associated with an increased risk of hip fracture in this l...Continue Reading

Citations

Apr 19, 2018·Frontiers in Neurology·Emma J FosterPhyo K Myint
May 26, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Daehoon KimBoyoung Joung
Mar 25, 2021·Journal of the American Heart Association·Huei-Kai HuangYu-Kang Tu
Dec 29, 2021·Journal of Women's Health·Tiffany CochranPelin Batur

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