Atrial Fibrillation, Cognitive Decline, and Dementia: an Epidemiologic Review

Current Epidemiology Reports
Mozhu Ding, Chengxuan Qiu

Abstract

Atrial fibrillation (AF) and dementia are both prevalent diseases in aging societies, which exert a great economic burden worldwide. Although a handful of epidemiologic studies have indicated that AF is independently associated with faster cognitive decline and a higher risk of dementia, there is still a lack of comprehensive understanding of the observed association. In this review, we summarize evidence from major epidemiologic studies concerning AF-related cognitive decline and dementia, the potential mechanisms underlying their association, and the cognitive benefits of treatment options. A large majority of population-based longitudinal studies have consistently shown an independent association of AF with cognitive decline and dementia with varying effect sizes, depending on the age of the study population and the presence of clinical stroke. The underlying pathways linking AF to cognitive phenotypes may involve systemic inflammation, cerebral hypoperfusion, and cerebral small vessel disease and microemboli. However, current evidence is insufficient to support the potential benefits of AF treatment in reducing risk of cognitive decline and dementia. Current epidemiologic research suggests that AF contributes to cognitive d...Continue Reading

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Citations

Feb 27, 2020·Expert Review of Medical Devices·Per InsulanderMats Jensen-Urstad
Nov 30, 2019·Frontiers in Aging Neuroscience·Md Mohaimenul IslamYu-Chuan Li
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Aug 25, 2021·American Heart Journal·Mathias Pinto BonnesenJesper Hastrup Svendsen
Oct 15, 2021·Heart·Sharon Louise CadoganCharlotte Warren-Gash

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Methods Mentioned

BETA
imaging techniques

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