Atrial fibrillation, cognitive impairment, frailty and disability in older heart failure patients

Journal of Cardiovascular Medicine
Giovanni PulignanoIMAGE-HF Study Investigators

Abstract

Aim of the study was to prospectively assess the relation between atrial fibrillation, cognitive impairment, frailty and disability in older patients with chronic heart failure . Three hundred thirty-one ambulatory community-living patients aged 70 years and older (mean 78 ± 6; range 70-93; 43% women) in stable conditions and optimized therapy were enrolled in seven heart failure cardiology clinics. Cognitive impairment was defined by a corrected Mini Mental State Examination score less than 24. Gait speed was used as marker of frailty and measured on a 4 m distance at usual pace. Ninety-eight patients (30%) were on atrial fibrillation at enrolment and 20 (6%) had a history of paroxysmal/persistent atrial fibrillation. Patients with atrial fibrillation were more frequently women with severe valvular disease, preserved left ventricular ejection fraction and less frequently on beta-blockers. At multivariable analyses, atrial fibrillation emerged as independently related to cognitive impairment [odds ratio (OR) 1.909 (1.072-3.397); P = 0.028], as well as to reduced gait speed [OR 4.366 (2.104-9.060); P < 0.001]. Furthermore, atrial fibrillation was significantly associated with disability in either basic or instrumental activities...Continue Reading

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Citations

Dec 8, 2016·Heart International·Giovanni PulignanoMassimo Uguccioni
Nov 16, 2016·Heart Failure Reviews·Pavlos G MyserlisAndreas P Kalogeropoulos
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Jul 1, 2020·Terapevticheskiĭ arkhiv·K E KrivoshapovaO L Barbarash
Jul 3, 2019·Heart, Lung & Circulation·Alireza Sepehri ShamlooArash Arya

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