Chronic kidney disease (CKD) and atrial fibrillation are common conditions that often coexist and are associated with increased risk of stroke. Despite the wealth of evidence for optimal management of atrial fibrillation in the general population, the role of anticoagulation with warfarin in individuals with CKD with atrial fibrillation is far less well defined. Current recommendations for anticoagulation in patients treated with dialysis and those with an earlier stage of CKD are based on clinical trials in the general atrial fibrillation population that have largely excluded individuals with CKD. Observational studies of anticoagulation in dialysis patients have produced conflicting results, mainly because of increased risk of bleeding. This, together with warfarin's potential adverse effects on ectopic/vascular calcification and progression of CKD, may result in negating the benefits associated with anticoagulation in the general population. With the recent emergence of novel oral anticoagulants, there is an urgent need for a better understanding of the complex inter-relationship among CKD, atrial fibrillation, stroke, and bleeding risk. This knowledge is paramount to optimize the potential benefits of treatment and minimize...Continue Reading
Coagulation and fibrinolysis in patients with chronic renal failure undergoing conservative treatment
A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
Endothelial dysfunction in chronic renal failure: roles of lipoprotein oxidation and pro-inflammatory cytokines
Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
Anemia and left ventricular hypertrophy in chronic kidney disease populations: a review of the current state of knowledge
Chronic kidney disease as a risk factor for bleeding complications after coronary artery bypass surgery
Chronic kidney disease, anemia, and incident stroke in a middle-aged, community-based population: the ARIC Study
Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study
Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease
Impaired endothelial release of tissue-type plasminogen activator in patients with chronic kidney disease and hypertension
Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirin
Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study
C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease
ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends
Prevalence of atrial fibrillation and associated factors in a population of long-term hemodialysis patients
Risk of bleeding and restenosis among chronic kidney disease patients undergoing percutaneous coronary intervention
The exclusion of patients with chronic kidney disease from clinical trials in coronary artery disease
Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin
Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study
Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes
Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality
Lower blood pressure and risk of recurrent stroke in patients with chronic kidney disease: PROGRESS trial
Renin angiotensin system blockade and cardiovascular outcomes in patients with chronic kidney disease and proteinuria: a meta-analysis
Impact of chronic kidney disease on major bleeding complications and mortality in patients with indication for oral anticoagulation undergoing coronary stenting
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study
Impact of decreased renal function on coagulation and fibrinolysis in patients with non-valvular atrial fibrillation
Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification
Warfarin use associates with increased risk for stroke in hemodialysis patients with atrial fibrillation
Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
Close bidirectional relationship between chronic kidney disease and atrial fibrillation: the Niigata preventive medicine study
Prevalence of atrial fibrillation and its predictors in nondialysis patients with chronic kidney disease
Atrial fibrillation in hemodialysis patients: clinical features and associations with anticoagulant therapy
A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease
Chronic kidney disease as an independent risk factor for new-onset atrial fibrillation in hypertensive patients
Chronic kidney disease and prevalent atrial fibrillation: the Chronic Renal Insufficiency Cohort (CRIC)
Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)
Association of chronic kidney disease with atrial fibrillation among adults in the United States: REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Chronic kidney disease in patients with acute intracerebral hemorrhage: association with large hematoma volume and poor outcome
Chronic kidney disease is prevalent in Chinese patients admitted with verified cerebrovascular lesions and predicts short-term prognosis
Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease
Incidence of stroke symptoms among adults with chronic kidney disease: results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study
Chronic kidney disease is associated with the incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study
Incidence of thromboembolic stroke and of major bleeding in patients with atrial fibrillation and chronic kidney disease treated with and without warfarin
Adults with late stage 3 chronic kidney disease are at high risk for prevalent silent brain infarction: a population-based study
The combination of chronic kidney disease and increased arterial stiffness is a predictor for stroke and cardiovascular disease in hypertensive patients
Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction
Chronic kidney disease and drinking status in relation to risks of stroke and its subtypes: the Circulatory Risk in Communities Study (CIRCS)
Atrial fibrillation, moderate chronic kidney disease, and stroke prevention: new anticoagulants, new hope
Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects
Effectiveness and safety of warfarin initiation in older hemodialysis patients with incident atrial fibrillation
The prevalence of and factors associated with chronic atrial fibrillation in Medicare/Medicaid-eligible dialysis patients
Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers
Kidney dysfunction at the time of intracerebral hemorrhage is associated with increased in-hospital mortality: a retrospective observational cohort study
Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study
A clinical decision aid for the selection of antithrombotic therapy for the prevention of stroke due to atrial fibrillation
Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease
Renal impairment in a "real-life" cohort of anticoagulated patients with atrial fibrillation (implications for thromboembolism and bleeding)
Estimated glomerular filtration rate is associated with major bleeding complications but not thromboembolic events, in anticoagulated patients taking warfarin
Relation of renal dysfunction to the increased risk of stroke and death in female patients with atrial fibrillation
Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)
Efficacy and safety of vitamin K-antagonists (VKA) for atrial fibrillation in non-dialysis dependent chronic kidney disease
Cardiovascular complications of calcium supplementation in chronic kidney disease: are there arrhythmic risks?
Stroke and Chronic Kidney Disease: Epidemiology, Pathogenesis, and Management Across Kidney Disease Stages
Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society
Meta-Analysis of Anticoagulation Use, Stroke, Thromboembolism, Bleeding, and Mortality in Patients With Atrial Fibrillation on Dialysis
Coronary Artery Calcium Assessment in CKD: Utility in Cardiovascular Disease Risk Assessment and Treatment?
Impact of renal function on survival after transcatheter aortic valve implantation (TAVI): an analysis of the UK TAVI registry
Atrial fibrillation and low vitamin D levels are associated with severe vascular calcifications in hemodialysis patients
Use of direct oral anticoagulants in patients with nonvalvular atrial fibrillation according to clinical profile
Effect of oral anticoagulant therapy on mortality in end-stage renal disease patients with atrial fibrillation: a prospective study
Safety and Clinical Outcomes of Catheter Ablation of Atrial Fibrillation in Patients With Chronic Kidney Disease
Advanced chronic kidney disease in patients undergoing transcatheter aortic valve implantation: insights on clinical outcomes and prognostic markers from a large cohort of patients
Influence of renal function on anticoagulation control in patients with non-valvular atrial fibrillation taking vitamin K antagonists
Variation of renal function over time is associated with major bleeding in patients treated with direct oral anticoagulants for atrial fibrillation
Safety and efficacy of apixaban versus warfarin in patients with end-stage renal disease: Meta-analysis
Anticoagulation for Stroke Prevention in Older Adults with Atrial Fibrillation and Comorbidity: Current Evidence and Treatment Challenges
Warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis
Direct oral anticoagulants versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation patients with chronic kidney disease
Atrial fibrillation in patients with end-stage renal disease on hemodialysis: Magnitude of the problem and new approach to oral anticoagulation
Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins
Effect of anticoagulation therapy in older patients with chronic kidney disease and atrial fibrillation: A meta-analysis
Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis
Impact of chronic kidney disease on Watchman implantation: experience with 300 consecutive left atrial appendage closures at a single center
Anti-thrombotic therapy for atrial fibrillation in patients with chronic kidney disease: Current views
Atherosclerosis Disease Progression
Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.
Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.
Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.
Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.
A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.
Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.
Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.
Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.
Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.
Blood Clotting Disorders
Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.
Cardiovascular Disease Pathophysiology
Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.