Atrial fibrillation is associated with high levels of monocyte-platelet-aggregates and increased CD11b expression in patients with aortic stenosis

Thrombosis and Haemostasis
Christian PflueckeKarim Ibrahim

Abstract

A growing body of evidence suggests a pivotal role of inflammatory processes in AF in a bidirectional manner. Infiltrating leukocytes seem to promote both structural and electrical remodelling processes in patients with AF. Monocyte-platelets-aggregates (MPAs) are sensitive markers of both platelets and monocyte activation. So far it is not clear whether the content of MPAs is affected by AF. The present study examined the content of MPAs and the activation of monocytes in elderly patients with an aortic stenosis in dependence of AF. These patients are known to have a high prevalence of AF. Flow-cytometric quantification analysis demonstrated that patients with AF have an increased content of MPAs (207 ± 13 cells/µl vs 307 ± 21 cells/µl, p< 0.001), and enhanced expression of CD11b on monocytes (p< 0.001), compared to patients in stable sinus rhythm (SR). The number of CD14+/CD16+ monocytes were only slightly elevated in patients with AF. These findings were seen in patients with permanent AF. But also patients with paroxysmal AF, even when presenting in SR, the MPAs were increased by 50 % (p< 0.05) as well as the CD11b expression, which was twice as high (p< 0.05) compared to stable SR. These results demonstrate for the first t...Continue Reading

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Citations

Nov 27, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·David AebisherJacek Tabarkiewicz
Sep 7, 2018·Journal of Cellular and Molecular Medicine·Małgorzata TomczyńskaJoanna Saluk-Bijak
Jun 14, 2018·Aging and Disease·Chengjie ZhangLing Wei
Aug 11, 2020·Biomarker Research·Yufei ChenWen Gao
Jan 12, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Daniel TarnowskiChristian Pfluecke
Jan 14, 2020·Journal of Agricultural and Food Chemistry·Takashi HosonoTaiichiro Seki

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