Sep 13, 2011

Atrial fibrillatory rate and irregularity of ventricular response as predictors of clinical outcome in patients with atrial fibrillation

Journal of Electrocardiology
Pyotr G Platonov, Fredrik Holmqvist


Atrial fibrillation (AF) remains the most common arrhythmia encountered in clinical practice. Electrocardiogram (ECG)-based predictors of clinical outcome, however, have mostly been studied during sinus rhythm, whereas noninvasive risk stratification of patients with AF remains largely unexplored. Advances in ECG signal processing have led to the development of noninvasive methods of atrial fibrillatory rate (AFR) assessment using spatiotemporal QRST cancellation and time frequency analysis that demonstrated its predictive value for the outcome of pharmacologic and catheter-based interventions for AF. Recently, the prognostic value of AFR was evaluated in patients with congestive heart failure and indicated that reduced AFR may be an independent predictor of total and congestive heart failure-related mortality. A high degree of irregularity of the RR intervals during AF and its dependence on the modulation of the atrioventricular conduction rather than sinus node automaticity hampers the use of conventional heart rate variability approach in patients with AF. However, RR irregularity measures that can be applied to short-time ECG recordings appear to be promising predictors of clinical outcome.

  • References22
  • Citations8


Mentioned in this Paper

Sinoatrial Node
Left Ventricle Remodeling
Left Ventricular Structure
Contraction (Finding)
Sinus - General Anatomical Term
Right Atrial Structure
Atrial Fibrillation
Holter Electrocardiography
Refractory Period

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