Atrial flutter with 1:1 conduction after administration of the antimalarial drug mefloquine

Clinical Cardiology
W FonteyneL Jordaens

Abstract

Antimalarial drugs are well known for their cardiovascular toxicity. Quinine, the most famous antimalarial agent, mostly causes bradycardia. Quinidine, its dextrorotatory isomer, may cause 1:1 atrioventricular (AV) conduction during atrial flutter. The newly developed drug mefloquine was reported to have fewer cardiac side effects. We describe a 63-year-old male patient with atrial flutter in whom mefloquine use was associated with 1:1 AV conduction, and who then responded to therapy with digoxin and sotalol. The patient had a history of palpitations. This case report emphasizes that mefloquine should be used with caution in patients with a history of palpitations or underlying heart disease.

References

Dec 1, 1992·Pacing and Clinical Electrophysiology : PACE·B OlshanskyR J Hariman
Jul 15, 1992·Annals of Internal Medicine·R H Falk
Aug 1, 1994·The Medical Journal of Australia·M Phillips

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Citations

Mar 23, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G LefèvreM S Thomsen
Sep 20, 2007·Expert Opinion on Drug Safety·Rana ChattopadhyaySanjai Kumar
Aug 30, 2006·The American Journal of Emergency Medicine·Huck Chin Chew, R Ponampalam
Apr 23, 2010·Expert Opinion on Pharmacotherapy·Esperança SeveneClara Menéndez
Jun 26, 1999·Journal of Travel Medicine·P Schlagenhauf
Jan 15, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W Robert J Taylor, Nicholas J White

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