Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation

Cardiovascular Research
Dragan OpacicSander Verheule

Abstract

Atrial fibrillation (AF) is the most common tachyarrhythmia in clinical practice. Over decades of research, a vast amount of knowledge has been gathered about the causes and consequences of AF related to cellular electrophysiology and features of the tissue structure that influence the propagation of fibrillation waves. Far less is known about the role of myocyte metabolism and tissue perfusion in the pathogenesis of AF. However, the rapid rates of electrical activity and contraction during AF must present an enormous challenge to the energy balance of atrial myocytes. This challenge can be met by scaling back energy demand and by increasing energy supply, and there are several indications that both phenomena occur as a result of AF. Still, there is ample evidence that these adaptations fall short of redressing this imbalance, which may represent a driving force for atrial electrical as well as structural remodelling. In addition, several 'metabolic diseases' such as diabetes, obesity, and abnormal thyroid function precipitate some well-known 'culprits' of the AF substrate such as myocyte hypertrophy and fibrosis, while some other AF risk factors, such as heart failure, affect atrial metabolism. This review provides an overview...Continue Reading

References

Jan 1, 1978·Physiological Reviews·C L Gibbs
Nov 1, 1991·Journal of Molecular and Cellular Cardiology·F Savabi, A Kirsch
Dec 15, 1991·The Biochemical Journal·D A Harris, A M Das
Jan 1, 1972·Pflügers Archiv : European journal of physiology·E BassengeD Stoian
Sep 7, 1973·The American Journal of Cardiology·W A NeillD N Sim
May 1, 1969·The American Journal of Physiology·R C BoerthP E Pool
Jun 1, 1966·Diseases of the Chest·N C Flowers, L G Horan
Aug 1, 1984·International Journal of Cardiology·J BusquetM J Davies
Jun 1, 1983·The American Journal of Cardiology·P A McHaleJ C Greenfield
Mar 1, 1981·Progress in Cardiovascular Diseases·A J Liedtke
Jan 1, 1995·Advances in Experimental Medicine and Biology·B O'RourkeE Marban
Oct 1, 1996·Circulation·E G DaoudF Morady
Apr 1, 1997·Circulation·R G TielemanH J Crijns
Jan 7, 1998·The American Journal of Cardiology·K SakataK Ishikawa
Mar 4, 2000·The New England Journal of Medicine·S H LeeP A Thistlethwaite
Mar 25, 2000·Journal of Molecular and Cellular Cardiology·J AusmaM Borgers
May 16, 2000·Journal of Cardiovascular Electrophysiology·O BarbeyJ M Maixent
Mar 27, 2001·Journal of Cardiac Failure·N TakahashiM Hashimoto

❮ Previous
Next ❯

Citations

Feb 10, 2016·Cardiovascular Research·Stanley Nattel, Dobromir Dobrev
Dec 1, 2017·Cardiovascular Research·Diane GalWouter Vandevelde
Dec 19, 2017·Journal of Atrial Fibrillation·Helmut WeberArmin Heinze
Nov 28, 2018·Journal of Cellular Physiology·Marinela Couselo-SeijasSonia Eiras
Sep 8, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Michael GhannamVenkatesh L Murthy
Sep 10, 2020·Frontiers in Cardiovascular Medicine·Zahra MariaVéronique A Lacombe
Feb 9, 2017·Current Heart Failure Reports·Hernando Vargas-Uricoechea, Anilza Bonelo-Perdomo
Feb 6, 2020·International Journal of Molecular Sciences·Hsiang-Chun Lee, Yi-Hsiung Lin
Sep 6, 2020·Animals : an Open Access Journal From MDPI·Alexandra Bizy, Matthew Klos
Apr 23, 2019·Experimental and Therapeutic Medicine·Zhi-Tao YanKang Zhou
Dec 2, 2020·Basic Research in Cardiology·Fleur E MasonNiels Voigt
Oct 23, 2020·Antioxidants·Blake H GowenJohn P Morrow
Mar 19, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Bianca J J M BrundelDeli Zhang
Jun 5, 2021·Journal of the American College of Cardiology·Yi Ching ChenJulie R McMullen
Jun 8, 2021·IJC Heart & Vasculature·Elton A M P DudinkSander Verheule
Aug 27, 2021·Circulation Research·Stephan R KünzelAli El-Armouche

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.