Atrial natriuretic factor receptor guanylate cyclase signaling: new ATP-regulated transduction motif.

Molecular and Cellular Biochemistry
T DudaR K Sharma

Abstract

ANF-RGC membrane guanylate cyclase is the receptor for the hypotensive peptide hormones, atrial natriuretic factor (ANF) and type B natriuretic peptide (BNP). It is a single transmembrane spanning protein. Binding the hormone to the extracellular domain activates its intracellular catalytic domain. This results in accelerated production of cyclic GMP, a second messenger in controlling blood pressure, cardiac vasculature, and fluid secretion. ATP is the obligatory transducer of the ANF signal. It works through its ATP regulated module, ARM, which is juxtaposed to the C-terminal side of the transmembrane domain. Upon interaction, ATP induces a cascade of temporal and spatial changes in the ARM, which, finally, result in activation of the catalytic module. Although the exact nature and the details of these changes are not known, some of these have been stereographed in the simulated three-dimensional model of the ARM and validated biochemically. Through comprehensive techniques of steady state, time-resolved tryptophan fluorescence and Forster Resonance Energy Transfer (FRET), site-directed and deletion-mutagenesis, and reconstitution, the present study validates and explains the mechanism of the model-based predicted transduction...Continue Reading

References

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Citations

Feb 10, 2016·Frontiers in Molecular Neuroscience·Teresa DudaRameshwar K Sharma
Apr 6, 2011·Biochemical and Biophysical Research Communications·Teresa DudaRameshwar K Sharma
Jun 18, 2010·The FEBS Journal·Teresa DudaRameshwar K Sharma
Jul 30, 2014·Frontiers in Molecular Neuroscience·Rameshwar K Sharma, Teresa Duda
Mar 29, 2014·Frontiers in Molecular Neuroscience·Teresa DudaRameshwar K Sharma
Oct 4, 2016·Frontiers in Molecular Neuroscience·Rameshwar K SharmaClint L Makino
Dec 4, 2009·Molecular and Cellular Biochemistry·Rameshwar K Sharma
Jul 8, 2016·Bulletin of Experimental Biology and Medicine·G I Lobov, M N Pan'kova
Nov 27, 2009·Molecular and Cellular Biochemistry·Teresa Duda

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