Atrial natriuretic factor-receptor guanylate cyclase signal transduction mechanism.

Molecular and Cellular Biochemistry
Teresa Duda

Abstract

Atrial natriuretic factor (ANF) receptor guanylate cyclase (ANF-RGC), like the other members of the membrane guanylate cyclase family, is a single transmembrane-spanning protein. The transmembrane domain separates the protein into two regions, extracellular and intracellular. The extracellular region contains the ANF-binding domain and the intracellular region the catalytic domain located at the C-terminus of the protein. Preceding the catalytic domain, the intracellular region is comprised of the following functional domains: juxtaposed 40 amino acids to the transmembrane domain is the ATP-regulated module (ARM) domain [also termed the kinase homology domain (KHD)], and the putative dimerization domain. The ANF-RGC signaling is initiated by hormone, ANF, binding to its extracellular binding site. The binding signal is transduced through the transmembrane domain to the intracellular portion where ATP binding to the ARM domain partially activates the cyclase and prepares it for subsequent steps involving phosphorylation and attaining the fully activated state. This chapter reviews the signaling modules of ANF-RGC.

References

Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T DudaR K Sharma
Oct 31, 1991·Biochemical and Biophysical Research Communications·D S ThorpeE Morkin
Nov 30, 1990·Cell·S SchulzD L Garbers
Apr 9, 1990·Biochimica Et Biophysica Acta·C H ChangF Murad
Mar 27, 1990·Molecular and Cellular Biochemistry·T Duda, R K Sharma
Apr 11, 1995·Biochemistry·E M Wilson, M Chinkers
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·H J FülleD L Garbers
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·D G LoweJ B Hurley
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·R B YangH J Fülle
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F K HamraC E Smith
Sep 30, 1994·Biochemical and Biophysical Research Communications·S KhareT A Brasitus
Jan 5, 1996·Biochemical and Biophysical Research Communications·A MargulisA Sitaramayya
Jan 26, 1996·Biochemical and Biophysical Research Communications·D S ThorpeE Morkin
Jul 2, 1996·Biochemistry·T DudaR K Sharma
Jan 1, 1996·Life Sciences·J L Bankers-FulbrightD J McKean

❮ Previous
Next ❯

Citations

Dec 9, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Zhenwei ShiHaifeng Zhang
Jun 27, 2019·Current Cardiology Reviews·Juan SalazarValmore Bermúdez
Jun 18, 2010·The FEBS Journal·Teresa DudaRameshwar K Sharma
Jan 19, 2018·Journal of Biological Engineering·Shihui FuLeiming Luo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.