PMID: 8945974Nov 11, 1996Paper

Atrial natriuretic peptide and sodium homeostasis in compensated heart failure

The American Journal of Physiology
T E LohmeierR H Didlake

Abstract

The purpose of this study was to determine whether high plasma levels of atrial natriuretic peptide (ANP) in compensated heart failure are important in the maintenance of sodium balance. This was achieved by subjecting eight dogs to bilateral atrial appendectomy (APX) to blunt the ANP response to pacing-induced heart failure. Five intact dogs served as controls. In controls, 14 days of left ventricular pacing at 240 beats/min produced a sustained fall in cardiac output and mean arterial pressure of approximately 40 and 20%, respectively; compared with cardiac output, reductions in renal blood flow (up to approximately 25%) were less pronounced and even smaller decrements in GFR occurred (up to 9%). Despite these changes and a threefold elevation in plasma norepinephrine concentration, plasma renin activity (PRA) did not increase and sodium balance was achieved during the second week of pacing in association with a six- to eightfold rise in plasma levels of ANP. Similar responses occurred in four dogs in which APX was relatively ineffective in blunting the ANP response to pacing. In marked contrast, there were substantial increments in PRA and in plasma norepinephrine concentration, and marked sodium and water retention during t...Continue Reading

Citations

Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T E LohmeierJ P Montani
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M T RademakerA M Richards

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