PMID: 8596707Feb 1, 1996Paper

Atrial natriuretic peptide attenuates flow in an isolated lymph duct preparation

Pflügers Archiv : European journal of physiology
D J Atchison, M G Johnston

Abstract

We investigated the hypothesis that atrial natriuretic peptide (ANP) attenuates lymph vessel pumping. In the present experiments, isolated bovine lymphatic vessels were cannulated at each end to create inflow and outlfow ports for the administration of Krebs' solution (vehicle) or ANP and for the measurement of fluid pumped by the vessel respectively. Once cannulated, the vessels were placed in a temperature-regulated bath circulated with oxygenated vehicle. Transmural pressure was regulated by the height of a fluid-filled reservoir. Lymph pump activity was assessed by measuring the volume of outlfow every ten minutes, ANP was administered at concentrations of 0 (control), 0.1, 1.0, 10 and 100 nM. Data were expressed as a percentage of the value in the control period. When compared with vehicle, ANP produced a significant inhibition of lymph pump activity by 7.7% at 0.1 nM, 24.2% at 10 nM and 38.26% at 100 nM averaged over the hour for which the vessels were exposed to each concentration. Thus ANP inhibits lymph pumping concentration dependently. This may be yet another mechanism by which ANP exerts its haemodynamic effects.

References

Apr 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·T OhhashiT Azuma
Aug 1, 1990·The American Journal of Physiology·M A CorsonM Schoenberg
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Citations

Mar 8, 2008·Cardiology in the Young·Shaji MenonDavid Driscoll
Oct 29, 2015·British Journal of Anaesthesia·P Marik, R Bellomo
Feb 19, 2005·The Journal of Physiology·Zoë L S Brookes, Susan Kaufman
Aug 18, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiaodong LiLinghui Zhao
Jul 8, 2016·Bulletin of Experimental Biology and Medicine·G I Lobov, M N Pan'kova

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