PMID: 7515565May 1, 1994Paper

Atrial natriuretic peptide enhances activity of potassium conductance in adrenal glomerulosa cells

The American Journal of Physiology
M B GanzP Q Barrett

Abstract

Aldosterone secretion from the adrenal glomerulosa (AG) cells is inhibited by atrial natriuretic peptide (ANP). Inasmuch as alterations in K+ conductance can modulate aldosterone secretion, the effect of ANP on intracellular K+ homeostasis was investigated. Intracellular K+ concentration ([K+]i) of AG cells was assessed by spectrofluorometry using the K(+)-sensitive dye, K(+)-binding benzofuran isophthalate. The resting value of [K+]i in AG cells was determined to be 120 +/- 1.2 mM (n = 37) in a HCO3-free, N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid-buffered medium. Exposure of AG cells to ANP led to a dose-dependent, transient decrease in [K+]i, from 21 +/- 3.2% (n = 7) at 100 pM to 31 +/- 2.3% at 1 microM (n = 7). In the continued presence of ANP, a rapid recovery to near basal values of [K+]i was attained within 90 s. Measurements of membrane voltage using the potential sensitive dye 1-3(-sulfonatopropyl)-4-[beta-(-(di-n-butylamino)-6-naphthyl)vinyl ]- pyridinium betaine documented an accompanying change in membrane potential. Pretreatment of AG cells with barium (0.5 mM), tetraethylammonium (0.1 mM), charybdotoxin (100 nM), or ethylene glycol-bis(beta-aminoethylether)-N,N,N',N'-tetraacetic acid (0.5 mM) blunted the ...Continue Reading

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Citations

Jul 23, 1998·Physiological Reviews·J D Stockand, S C Sansom
Sep 16, 1998·Natural Product Reports·P S Steyn, F R van Heerden
Jul 10, 1999·Scandinavian Journal of Clinical and Laboratory Investigation·K Kimura, I Nishio
Aug 24, 1999·The Journal of Physiology·J R HirschE Schlatter
Jan 26, 1999·Medicinal Research Reviews·J I Kourie, M J Rive
Oct 24, 2014·Pflügers Archiv : European journal of physiology·Sascha BandulikRichard Warth
May 29, 2000·The Journal of Biological Chemistry·M F RomeroC M Sciortino
Nov 20, 2016·Acta Physiologica·S Bandulik
Jun 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·A PaciS Ghoine

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