PMID: 15374090Sep 18, 2004Paper

Atrial natriuretic peptide in aged patients with iron deficiency anemia

Archives of Gerontology and Geriatrics
M Kikuchi, T Inagaki

Abstract

Anemia is a common disease in elderly people. However, since hemoglobin concentration often decreases subclinically with aging because of nutritional impairment, its pathological significance is unclear. To investigate the pathological significance of low hemoglobin concentration, we studied the relation between hemoglobin levels and arrhythmia, as well as circulatory parameters. Arrhythmia was detected by Holter type ambulatory electrocardiography in 42 elderly people (aged 60 or over) living in a nursing home. Plasma concentrations of human atrial natriuretic peptide (hANP) after iron therapy were determined by immunoradiometric assay. Changes in circulatory parameters in elderly people with iron deficiency anemia were examined. Supraventricular and ventricular premature contractions significantly increased in elderly people with low hemoglobin concentrations or hematocrit. hANP increased significantly as the hemoglobin concentration decreased in 22 elderly people. Of these 22 subjects, 11 showed a low serum concentration of iron, and were administered ferrous salts. No side effects, such as nausea, occurred. After iron supplementation, the average hemoglobin level increased from 9.0 to 10.5 g/dl, and the average hANP level w...Continue Reading

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Citations

Sep 18, 2001·Journal of the American Geriatrics Society·M KikuchiN Shinagawa
Apr 5, 2017·Pediatric Emergency Care·Daniel J Corwin, Richard J Scarfone
Dec 23, 2020·Journal of Electrocardiology·Emre Yilmaz, Ercan Aydin

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