Abstract
Anemia is a common disease in elderly people. However, since hemoglobin concentration often decreases subclinically with aging because of nutritional impairment, its pathological significance is unclear. To investigate the pathological significance of low hemoglobin concentration, we studied the relation between hemoglobin levels and arrhythmia, as well as circulatory parameters. Arrhythmia was detected by Holter type ambulatory electrocardiography in 42 elderly people (aged 60 or over) living in a nursing home. Plasma concentrations of human atrial natriuretic peptide (hANP) after iron therapy were determined by immunoradiometric assay. Changes in circulatory parameters in elderly people with iron deficiency anemia were examined. Supraventricular and ventricular premature contractions significantly increased in elderly people with low hemoglobin concentrations or hematocrit. hANP increased significantly as the hemoglobin concentration decreased in 22 elderly people. Of these 22 subjects, 11 showed a low serum concentration of iron, and were administered ferrous salts. No side effects, such as nausea, occurred. After iron supplementation, the average hemoglobin level increased from 9.0 to 10.5 g/dl, and the average hANP level w...Continue Reading
References
Jan 1, 1977·Gerontology·P PflugfelderR D Cape
Oct 1, 1992·The Journal of Physiology·N HagiwaraH Irisawa
Mar 10, 1991·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·H Yasuda
Sep 11, 1991·Circulation Research·D E HansenL K Taylor
Apr 30, 1990·Biochemical and Biophysical Research Communications·T SudohH Matsuo
Jun 1, 1989·Journal of the American College of Cardiology·S S GottliebM Packer
May 29, 1986·Biochemical and Biophysical Research Communications·F MarumoM Kawakami
Aug 16, 1986·British Medical Journal·A M RichardsJ I Robertson
Feb 1, 1986·The American Journal of Cardiology·J W CornynC V Leier
Jan 1, 1984·Mechanisms of Ageing and Development·D A Lipschitz, K B Udupa
Mar 1, 1982·Chest·J L Fleg, H L Kennedy
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D HarnettP S Parfrey
Nov 1, 1994·British Heart Journal·A SigurdssonK Swedberg
Dec 1, 1994·British Heart Journal·M YoshimuraK Nakao
Jan 1, 1994·Blood Purification·P S Parfrey, J D Harnett
Mar 1, 1995·The Journal of Clinical Investigation·T L StevensM M Redfield
Jul 1, 1994·Circulation·H YasueK Nakao
May 17, 1996·Biochemical Pharmacology·T Obata, Y Yamanaka
Oct 19, 1996·Lancet·J L CarsonB L Strom
Citations
Jul 27, 2006·International Urology and Nephrology·Donald S SilverbergDoron Schwartz
Sep 18, 2001·Journal of the American Geriatrics Society·M KikuchiN Shinagawa
Feb 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Ichiro TakeuchiTohru Izumi
Jul 27, 2005·International Heart Journal·Toshimi KoitabashiTohru Izumi
Apr 5, 2017·Pediatric Emergency Care·Daniel J Corwin, Richard J Scarfone
Mar 9, 2017·Pediatric Cardiology·Cem KaradenizNurettin Ünal
Dec 23, 2020·Journal of Electrocardiology·Emre Yilmaz, Ercan Aydin