Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume.

The Journal of Physiology
Fitz-Roy E CurryRolf K Reed

Abstract

Atrial natriuretic peptide (ANP) via its guanylyl cyclase-A (GC-A) receptor participates in regulation of arterial blood pressure and vascular volume. Previous studies demonstrated that concerted renal diuretic/natriuretic and endothelial permeability effects of ANP cooperate in intravascular volume regulation. We show that the microvascular endothelial contribution to the hypovolaemic action of ANP can be measured by the magnitude of the ANP-induced increase in blood-to-tissue albumin transport, measured as plasma albumin clearance corrected for intravascular volume change, relative to the corresponding increase in ANP-induced renal water excretion. We used a two-tracer method with isotopically labelled albumin to measure clearances in skin and skeletal muscle of: (i) C57BL6 mice; (ii) mice with endothelium-restricted deletion of GC-A (floxed GC-A x tie2-Cre: endothelial cell (EC) GC-A knockout (KO)); and (iii) control littermates (floxed GC-A mice with normal GC-A expression levels). Comparison of albumin clearances in hypervolaemic EC GC-A KO mice with normovolaemic littermates demonstrated that skeletal muscle albumin clearance with ANP treatment accounts for at most 30% of whole body clearance required for ANP to regulate ...Continue Reading

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Citations

Nov 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cecilie B RyghKatherine W Ferrara
Sep 23, 2010·Basic Research in Cardiology·Bernhard F BeckerMatthias Jacob
Feb 5, 2013·Acta Physiologica·F-R E Curry, R H Adamson
Jan 10, 2012·British Journal of Pharmacology·Michaela Kuhn
Jan 13, 2015·Toxicology Mechanisms and Methods·Aarón Emmanuel González-EsquivelAna Rosa Rincón-Sánchez
Apr 21, 2016·Acta Physiologica·R K KopperudS O Døskeland
Oct 25, 2016·Seminars in Dialysis·Bengt Rippe, Carl M Öberg
Sep 11, 2013·Annals of Biomedical Engineering·Shengping QinKatherine W Ferrara
Apr 1, 2016·Physiological Reviews·Michaela Kuhn
Jan 19, 2010·The Journal of Physiology·Rupert M Pearse
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Tine V KarlsenHelge Wiig
Oct 15, 2010·American Journal of Physiology. Renal Physiology·Josefin AxelssonBengt Rippe

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