PMID: 8600124Sep 1, 1995Paper

Atrial natriuretic peptide participates in the regulation of vestibular blood flow

Hearing Research
J D RachelW S Quirk

Abstract

Atrial natriuretic peptide (ANP) is a cardiac hormone which exerts natriuretic, diuretic and vasorelaxant effects. Among the many organs and vascular beds populated with ANP receptors (Genest and Cantin, 1988) are the vestibular and auditory organs of the inner ear (Lamprecht and Meyer zum Gottesberge, 1988). The purpose of the current study was to assess the potential influence of ANP on vestibular blood flow in the guinea pig. The inner ear was exposed with a posterior-lateral approach medially through the mastoid cortex. The laser Doppler probe was placed adjacent to the ampulla of the posterior semicircular canal. Baseline measurements of mean blood pressure (BP), heart rate (HR) and vestibular blood flow were established. ANP dissolved in physiologic saline was infused intravenously at concentrations of 15, 150 or 300 ng/kg/min at 10 microliters/min for 30 min. Measurements were recorded during the infusion and for a recovery period of 65 min. The control group was treated equivalently and infused with 0.15 M NaCl. Baseline BP and HR for all animals were 40.1 +/- 6.67 and 190 +/- 15.7, respectively. BP, HR and vestibular blood flow remained stable during the baseline, control and recovery conditions of saline infused subje...Continue Reading

References

Nov 1, 1991·Hearing Research·A M Meyer zum GottesbergeW G Forssmann
Jan 1, 1991·Acta Oto-laryngologica·T NakashimaN Yanagita
Aug 1, 1989·Hearing Research·W S QuirkJ W Wright
Jan 1, 1988·Archives of Oto-rhino-laryngology·J Lamprecht, A M Meyer zum Gottesberge
Mar 27, 1986·The New England Journal of Medicine·P Needleman, J E Greenwald
Jul 16, 1986·Biochemical and Biophysical Research Communications·M B Anand-Srivastava, M Cantin
Nov 1, 1988·American Journal of Otolaryngology·J M Miller, H Dengerink
Mar 1, 1986·American Journal of Otolaryngology·R S Kimura
Sep 17, 1984·Biochemical and Biophysical Research Communications·P HametJ Genest
Sep 1, 1983·Hearing Research·J M MillerP C Goodwin
May 1, 1993·Hearing Research·M J Lyon, H H Wanamaker
Oct 1, 1993·Hypertension·G Y KohL J Field

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Citations

Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J G ArenbergW S Quirk
Nov 27, 2002·The Annals of Otology, Rhinology, and Laryngology·John L DornhofferShulin Li
Apr 13, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·T D DoerrW S Quirk
Jun 30, 2018·Physiological Genomics·Janet L Fitzakerley, George J Trachte
Jan 27, 1998·Acta Oto-laryngologica·D L BurgioW S Quirk
May 14, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Ryan T BooneJohn Dornhoffer
Mar 4, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J K DziadziolaW S Quirk

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