Abstract
The mechanism of atrial natriuretic peptide (ANP) release has been difficult to demonstrate in patient studies because of inaccuracies in measuring atrial volumes using conventional techniques. Magnetic resonance imaging was performed in 28 clinically stable patients (New York Heart Association class 3) with chronic heart failure to determine right atrial (RA), left atrial (LA), and ventricular volumes. In addition, right heart catheterization was serially performed and plasma ANP levels (in picograms per milliliter) were drawn from the right atrium. Five patients had to be excluded from data analysis for technical reasons. The remaining 23 patients had the following hemodynamic measurements (mean +/- SD): RA mean pressure 7+/-5 mm Hg, pulmonary artery mean pressure 28+/-10, pulmonary capillary wedge pressure 21+/-8 mm Hg, and cardiac index 2.9+/-1.4 (L/min/m2), respectively. Plasma ANP levels were significantly elevated at 162+/-117 (normal range 20 to 65 pg/ml, p < 0.05), as were LA and RA volumes compared with healthy controls (RA volume 128+/-64 ml vs 82+/-25 ml, p < 0.05; LA volume 157+/-54 ml vs 71+/-24 ml, p < 0.01, respectively). ANP showed a stronger relation with atrial volumes (RA volume, r = 0.91, p = 0.0001; LA vol...Continue Reading
References
Sep 1, 1989·Journal of Internal Medicine·N KellerO Henriksen
Nov 1, 1989·Magnetic Resonance Imaging·D GlogarH Mayr
Mar 7, 1986·Science·J C BurnettG S Reeder
Jun 1, 1986·Circulation·E R BatesR J Grekin
Aug 1, 1986·Clinical Science·J V AndersonS R Bloom
Jun 1, 1986·Hypertension·A S HollisterT Inagami
Aug 28, 1986·The New England Journal of Medicine·A E RaineF R Bühler
Feb 1, 1988·Circulation Research·B S EdwardsJ C Burnett
Jul 1, 1988·American Heart Journal·H LeinonenF Fyhrquist
Mar 21, 1985·Nature·R E LangT Unger
Sep 1, 1985·Radiology·R B RehrR M Peshock
Jan 15, 1983·The American Journal of Cardiology·J GutmanN B Schiller
Jan 5, 1981·Life Sciences·A J de BoldH Sonnenberg
Mar 15, 1995·Journal of the American College of Cardiology·D FreimarkL S Czer
Mar 1, 1994·Critical Care Medicine·C LeithnerM Röggla
Nov 1, 1993·Angiology·H KawakamiK Hiwada
Apr 1, 1993·Angiology·H MatsuokaT Sumimoto
Mar 1, 1996·Journal of the American College of Cardiology·R PacherG Maurer
Citations
Jun 22, 1999·Journal of Cardiovascular Electrophysiology·A E TuinenburgH J Crijns
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Beata Wozakowska-Kaplon, Grzegorz Opolski
Oct 16, 2004·Chest·Lok Bin YapJohn Gerard Coghlan
Jan 14, 2016·Diabetology & Metabolic Syndrome·David NathansonThomas Nyström
Jan 1, 2014·Echocardiography·Naoyasu YoshidaHironori Ueda
Sep 17, 2004·Clinical Biochemistry·Lok B YapPeter M Timms
Jun 14, 2003·The American Journal of Cardiology·Anna Vittoria MattioliGiorgio Mattioli
Mar 17, 2015·Pediatric Cardiology·Yuki NakamuraHiromichi Nakajima
Apr 12, 2000·Journal of the American College of Cardiology·A RossiJ B Seward
Sep 27, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Laurent SuissaMarie Hélène Mahagne
Aug 23, 2002·European Journal of Clinical Investigation·N DzimiriZ Al-Halees
Apr 5, 2001·Journal of Clinical Pharmacy and Therapeutics·J Venugopal
Jun 5, 2003·Heart Disease·George Stoupakis, Marc Klapholz
Nov 22, 2001·Japanese Circulation Journal·F NakaoM Matsuzaki
Aug 18, 2001·Journal of Endocrinological Investigation·B Mazul-SunkoE Topic
Apr 3, 2003·Critical Care Nursing Quarterly·Lauren Saul, Melanie Shatzer
Feb 15, 2001·Critical Care Medicine·K J HarteminkL G Thijs
May 28, 2019·Regional Anesthesia and Pain Medicine·Rune B StrandbyLars B Svendsen